Phenotypes associated with this allele

• Allele Symbol: Pparg^tm1.1Unc
• Allele Name: targeted mutation 1.1, University of North Carolina
• Allele ID: MGI:4412008
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pparg^tm1.1Unc/Pparg^tm1.1Unc	involves: 129S6/SvEvTac * C57BL/6J	MGI:4412010
ht2	Pparg^tm1.1Unc/Pparg^+	involves: 129S6/SvEvTac * C57BL/6J	MGI:4412012

Genotype
MGI:4412010

hm1

• Allelic Composition: Pparg^tm1.1Unc/Pparg^tm1.1Unc
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased systemic arterial blood pressure ( J:154767 )

• blood pressure is lower in mice on a high fat diet at 8 months of age compared to wild-type littermate controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:154767 )

N • unlike glucose tolerance, insulin tolerance is similar to wild-type littermates

impaired glucose tolerance ( J:154767 )

• slower glucose clearance than their wild-type littermates following a glucose load as well as a significantly higher plasma glucose levels 120 min after a glucose load

Genotype
MGI:4412012

ht2

• Allelic Composition: Pparg^tm1.1Unc/Pparg⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

cardiovascular system

decreased systemic arterial blood pressure ( J:154767 )

• in females at 4 months of age

• overall, increased Pparg expression correlates with decreased blood pressure