All Phenotypes Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz/0 Tg(Thy1-MAPT)183Gotz/0
Genetic Background	B6.Cg-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz Tg(Thy1-MAPT)183Gotz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz mutation (1 available)
Tg(Thy1-MAPT)183Gotz mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:154968 )

• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice

• amyloid beta deposits worsen with age

tau protein deposits ( J:154968 )

• at 4 months, mice exhibit tau plaques unlike wild-type mice

• tau deposits worsen with age

behavior/neurological

abnormal spatial learning ( J:154968 )

• in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2 and 4 months compared with wild-type mice

• in a Morris water maze, mice exhibit exhibited decreased spatial learning at 4 and 12 months compared with wild-type mice

increased locomotor activity ( J:154968 )

• in a novel arena at 2 and 12 months but not at 4 months

homeostasis/metabolism

amyloid beta deposits ( J:154968 )

• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice

• amyloid beta deposits worsen with age

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease	DOID:10652		J:154968
cerebral amyloid angiopathy	DOID:9246		J:154968

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:165986 )

• at 4 weeks, mice exhibit a decrease in the number of surviving CldU+ cells in the dentate gyrus compared with wild-type mice

• however, proliferation of neuronal progenitors is normal

amyloid beta deposits ( J:154968 )

• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice

• amyloid beta deposits worsen with age

enhanced long-term potentiation ( J:165986 )

• induced by tetanic stimulation independent of age and amyloid plaque deposition

increased post-tetanic potentiation ( J:165986 )

• induced by tetanic stimulation

behavior/neurological

abnormal spatial learning ( J:154968 )

• in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2 and 4 months compared with wild-type mice

• in a Morris water maze, mice exhibit exhibited decreased spatial learning at 4 and 12 months compared with wild-type mice

impaired coordination ( J:154968 )

• on at rotarod at 4 months

growth/size/body

increased body weight ( J:154968 )

• at 4 to 12 months

cellular

abnormal neuron differentiation ( J:165986 )

• at 4 weeks, mice exhibit a decrease in the number of surviving CldU+ cells in the dentate gyrus compared with wild-type mice

• however, proliferation of neuronal progenitors is normal

homeostasis/metabolism

amyloid beta deposits ( J:154968 )

• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice

• amyloid beta deposits worsen with age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cerebral amyloid angiopathy		DOID:9246		J:165986

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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