About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prnptm1Lnq
targeted mutation 1, Susan Lindquist
MGI:4412098
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prnptm1Lnq/Prnptm1Lnq involves: 129P2/OlaHsd * C57BL/6N MGI:4412279


Genotype
MGI:4412279
hm1
Allelic
Composition		 Prnptm1Lnq/Prnptm1Lnq
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Lnq mutation (0 available); any Prnp mutation (142 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to prion infection ( J:154937 )
• mice are resistant to laboratory mouse prion strain infection unlike wild-type mice
• however, mice are normally sensitive to hamster scrapie infection

nervous system
nervous system phenotype ( J:154937 )
N
• mice do not develop spontaneous neuropathology




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory