Analysis Tools
behavior/neurological
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• increased exploratory behavior observed in open and closed arms of plus maze and open field test
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• mice exhibit an enhanced spatial learning by locating the visible and hidden platforms of the Morris water maze in less time than controls
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• mice exhibit an accelerated retrieval of spatial memory by remaining in target quadrant of probe trial (platform removed from water maze)
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• mice are more active than controls
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• increased number of rearing events in the open field test
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• mice exhibit increased sensitivity to handling-induced seizures
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nervous system
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• mice exhibit increased sensitivity to handling-induced seizures
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• I/O function, a measure of synaptic strength, in untrained mice is significantly impaired relative to controls
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• LTP induced in hippocampal slices is higher than controls, however synapse numbers are not increased
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