Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym targeted mutation 7, Susan Dymecki MGI:4412286 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal contextual fear conditioning and prepulse mediated inhibition of acoustic startle reflex
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• 5HT+ axon varicosities are enlarged compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• aberrant foot print angles, irregular and reduced stride lengths
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• parallel fibers accumulate unreleased synaptic vesicles unlike in wild-type cells
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• stimulation of parallel fibers fails to stimulate an excitatory postsynaptic current (EPSC) unlike in similarly treated wild-type mice
• however, extremely high stimulus intensities evoke an EPSC and stimulated parallel fibers propagate action potentials normally
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• mice exhibit auditory defects
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• heart rate is slower by 6-10% at P5 and P8
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• mice are less averse to open, brightly lit spaces compared with wild-type mice
• female mice exhibit decreased anxiety-related behaviors in open field, zero-maze, and light-dark tests compared with wild-type mice
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• pups are smaller than controls by 15-21% at P5 and P8
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• 5HT+ axon varicosities are enlarged compared to in wild-type mice
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• oxygen consumption is slightly but significantly lower at P5 and higher at P12
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• autoresuscitation is less effective compared to controls following repeated episodic exposure to anoxia and results in increased mortality at P5 and P8, with only 16% of pups surviving to the endpoint at P12; deaths occur during the anoxic challenge
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• tidal volume is increased by 18-34% at P8 and P12
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• increase in baseline breathing variability at P5
• autoresuscitation is less effective compared to controls following repeated episodic exposure to anoxia and results in increased mortality at P5 and P8, with only 16% of pups surviving to the endpoint at P12
• pups exposed to anoxia that die at P5 take 4 times longer to initiate gasping and 4 times longer to recover heart rate and eupneic breathing to 90% of baseline
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• 28% larger minute ventilation at P12
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| sudden infant death syndrome | DOID:9007 |
OMIM:272120 |
J:231745 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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