Phenotypes associated with this allele

• Allele Symbol: Nkx6-2^{tm1(cre/ERT2)Fsh}
• Allele Name: targeted mutation 1, Gordon Fishell
• Allele ID: MGI:4412372
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nkx6-2^tm1(cre/ERT2)Fsh/Nkx6-2^tm1(cre/ERT2)Fsh	involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster	MGI:4412376
cn2	Gt(ROSA)26Sor^tm1.1(CAG-EGFP)Fsh/Gt(ROSA)26Sor^+ Nkx6-2^tm1Qiu/Nkx6-2^tm1(cre/ERT2)Fsh	involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster	MGI:4412378

Genotype
MGI:4412376

hm1

• Allelic Composition: Nkx6-2^{tm1(cre/ERT2)Fsh}/Nkx6-2^{tm1(cre/ERT2)Fsh}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:155164 )

N • mice are born in normal Mendelian ratios and survive to adulthood similar to Nkx6-2^tm1Qiu homozygotes

Genotype
MGI:4412378

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1.1(CAG-EGFP)Fsh}/Gt(ROSA)26Sor⁺; Nkx6-2^tm1Qiu/Nkx6-2^{tm1(cre/ERT2)Fsh}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

nervous system

abnormal brain interneuron morphology ( J:155164 )

• following tamoxifen treatment at E12.5, mice exhibit a small and partially penetrant loss of delayed non-fast spiking somatostatin/calretinin double positive cortical interneurons compared with wild-type mice