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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wnt5btm1Tmj
targeted mutation 1, Thomas M Jessell
MGI:4412383
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wnt5btm1Tmj/Wnt5btm1Tmj Not Specified MGI:4412401
cx2
 		Wnt4tm1Amc/Wnt4tm1Amc
Wnt5atm1Amc/Wnt5atm1Amc
Wnt5btm1Tmj/Wnt5btm1Tmj 		involves: 129S1/Sv * 129S7/SvEvBrd MGI:4412392
cx3
 		Wnt4tm1Amc/Wnt4tm1Amc
Wnt5btm1Tmj/Wnt5btm1Tmj 		involves: 129S1/Sv * 129S7/SvEvBrd MGI:4412396
cx4
 		Wnt4tm1Amc/Wnt4+
Wnt5atm1Amc/Wnt5atm1Amc
Wnt5btm1Tmj/Wnt5btm1Tmj 		involves: 129S1/Sv * 129S7/SvEvBrd MGI:4412398
cx5
 		Wnt4tm1Amc/Wnt4tm1Amc
Wnt5atm1Amc/Wnt5a+
Wnt5btm1Tmj/Wnt5btm1Tmj 		involves: 129S1/Sv * 129S7/SvEvBrd MGI:4412399
cx6
 		Wnt4tm1Amc/Wnt4tm1Amc
Wnt5atm1Amc/Wnt5atm1Amc
Wnt5btm1Tmj/Wnt5b+ 		involves: 129S1/Sv * 129S7/SvEvBrd MGI:4412400
cx7
 		Wnt5atm1Amc/Wnt5atm1Amc
Wnt5btm1Tmj/Wnt5btm1Tmj 		involves: 129S7/SvEvBrd MGI:4412397


Genotype
MGI:4412401
hm1
Allelic
Composition		 Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt5btm1Tmj mutation (0 available); any Wnt5b mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:155074 )
N
• mice exhibit normal numbers of thoracic motor neurons and proportions of motor columnar subtypes




Genotype
MGI:4412392
cx2
Allelic
Composition		 Wnt4tm1Amc/Wnt4tm1Amc
Wnt5atm1Amc/Wnt5atm1Amc
Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt4tm1Amc mutation (2 available); any Wnt4 mutation (21 available)
Wnt5atm1Amc mutation (1 available); any Wnt5a mutation (42 available)
Wnt5btm1Tmj mutation (0 available); any Wnt5b mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:155074 )
• embryos die before the onset of motor neuron differentiation




Genotype
MGI:4412396
cx3
Allelic
Composition		 Wnt4tm1Amc/Wnt4tm1Amc
Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt4tm1Amc mutation (2 available); any Wnt4 mutation (21 available)
Wnt5btm1Tmj mutation (0 available); any Wnt5b mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal motor neuron morphology ( J:155074 )
• at E13.5, median motor column motor neurons at the thoracic level are decreased 58% compared to in wild-type mice
• mice exhibit a 50% reduction in median motor column motor neurons at the lumbar level compared with wild-type mice
• at the hind-limb level, the total number of motor neurons is slightly decreased and the ratio of median motor column motor neurons is decreased 50% compared to in wild-type mice
• at E13.5, hypaxial motor column motor neurons at the thoracic level are increased compared to in wild-type mice
decreased motor neuron number ( J:155074 )
• at the hind-limb level, the total number of motor neurons is slightly decreased compared to in wild-type mice




Genotype
MGI:4412398
cx4
Allelic
Composition		 Wnt4tm1Amc/Wnt4+
Wnt5atm1Amc/Wnt5atm1Amc
Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt4tm1Amc mutation (2 available); any Wnt4 mutation (21 available)
Wnt5atm1Amc mutation (1 available); any Wnt5a mutation (42 available)
Wnt5btm1Tmj mutation (0 available); any Wnt5b mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal motor neuron morphology ( J:155074 )
• at E13.5, median motor column motor neurons at the thoracic level are decreased 59% compared to in wild-type mice
• at E13.5, hypaxial motor column motor neurons at the thoracic level are increased 62% compared to in wild-type mice

limbs/digits/tail




Genotype
MGI:4412399
cx5
Allelic
Composition		 Wnt4tm1Amc/Wnt4tm1Amc
Wnt5atm1Amc/Wnt5a+
Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt4tm1Amc mutation (2 available); any Wnt4 mutation (21 available)
Wnt5atm1Amc mutation (1 available); any Wnt5a mutation (42 available)
Wnt5btm1Tmj mutation (0 available); any Wnt5b mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal motor neuron morphology ( J:155074 )
• at E13.5, hypaxial motor column motor neurons at the thoracic level are increased 50% compared to in wild-type mice
• at E13.5, median motor column motor neurons at the thoracic level are decreased 63% compared to in wild-type mice
• mice exhibit a 50% reduction in median motor column motor neurons at the lumbar level compared with wild-type mice
• at the hind limb level, the total number of motor neurons is decreased 20% while the ratio of median motor column motor neurons is decreased 50% compared to in wild-type mice
decreased motor neuron number ( J:155074 )
• at the hind limb level, the total number of motor neurons is decreased 20% compared to in wild-type mice

limbs/digits/tail




Genotype
MGI:4412400
cx6
Allelic
Composition		 Wnt4tm1Amc/Wnt4tm1Amc
Wnt5atm1Amc/Wnt5atm1Amc
Wnt5btm1Tmj/Wnt5b+
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt4tm1Amc mutation (2 available); any Wnt4 mutation (21 available)
Wnt5atm1Amc mutation (1 available); any Wnt5a mutation (42 available)
Wnt5btm1Tmj mutation (0 available); any Wnt5b mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal motor neuron morphology ( J:155074 )
• at E13.5, median motor column motor neurons at the thoracic level are decreased 67% compared to in wild-type mice
• at E13.5, hypaxial motor column motor neurons at the thoracic level are increased 39% compared to in wild-type mice

limbs/digits/tail




Genotype
MGI:4412397
cx7
Allelic
Composition		 Wnt5atm1Amc/Wnt5atm1Amc
Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt5atm1Amc mutation (1 available); any Wnt5a mutation (42 available)
Wnt5btm1Tmj mutation (0 available); any Wnt5b mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal motor neuron morphology ( J:155074 )
• at E13.5, median motor column motor neurons at the thoracic level are decreased 50% compared to in wild-type mice
• at E13.5, hypaxial motor column motor neurons at the thoracic level are increased compared to in wild-type mice

limbs/digits/tail




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory