nervous system
N |
• mice exhibit normal numbers of thoracic motor neurons and proportions of motor columnar subtypes
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Allele Symbol Allele Name Allele ID |
Wnt5btm1Tmj targeted mutation 1, Thomas M Jessell MGI:4412383 |
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Summary |
7 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice exhibit normal numbers of thoracic motor neurons and proportions of motor columnar subtypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• embryos die before the onset of motor neuron differentiation
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• at E13.5, median motor column motor neurons at the thoracic level are decreased 58% compared to in wild-type mice
• mice exhibit a 50% reduction in median motor column motor neurons at the lumbar level compared with wild-type mice
• at the hind-limb level, the total number of motor neurons is slightly decreased and the ratio of median motor column motor neurons is decreased 50% compared to in wild-type mice
• at E13.5, hypaxial motor column motor neurons at the thoracic level are increased compared to in wild-type mice
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• at the hind-limb level, the total number of motor neurons is slightly decreased compared to in wild-type mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• at E13.5, median motor column motor neurons at the thoracic level are decreased 59% compared to in wild-type mice
• at E13.5, hypaxial motor column motor neurons at the thoracic level are increased 62% compared to in wild-type mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• at E13.5, median motor column motor neurons at the thoracic level are decreased 63% compared to in wild-type mice
• mice exhibit a 50% reduction in median motor column motor neurons at the lumbar level compared with wild-type mice
• at the hind limb level, the total number of motor neurons is decreased 20% while the ratio of median motor column motor neurons is decreased 50% compared to in wild-type mice
• at E13.5, hypaxial motor column motor neurons at the thoracic level are increased 50% compared to in wild-type mice
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• at the hind limb level, the total number of motor neurons is decreased 20% compared to in wild-type mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• at E13.5, median motor column motor neurons at the thoracic level are decreased 67% compared to in wild-type mice
• at E13.5, hypaxial motor column motor neurons at the thoracic level are increased 39% compared to in wild-type mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• at E13.5, median motor column motor neurons at the thoracic level are decreased 50% compared to in wild-type mice
• at E13.5, hypaxial motor column motor neurons at the thoracic level are increased compared to in wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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