All Phenotypes Ret<tm1Ddg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ret^tm1Ddg
targeted mutation 1, David D Ginty
MGI:4413350

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mrgprd^tm1Mjz/? Ret^tm1Ddg/Ret^tm1Ddg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129 * 129S1/Sv * C57BL/6 * C57BL/6J * CBA/J	MGI:4413446
cn2	Ret^tm1Ddg/Ret^tm1Ddg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129 * C57BL/6 * C57BL/6J * CBA/J	MGI:4413445

Allelic Composition	Mrgprd^tm1Mjz/? Ret^tm1Ddg/Ret^tm1Ddg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129 * 129S1/Sv * C57BL/6 * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Mrgprd^tm1Mjz mutation (2 available); any Mrgprd mutation (26 available)
Ret^tm1Ddg mutation (0 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neurite morphology ( J:126484 )

• at P14, GFP+ skin neuron projections are reduced and punctate unlike in control Mrgprd^tm1Mjz Ret^tm1Ddg homozygotes

• however, central axonal projections in the thoracic spinal cord exhibit normal lamina specific innervation of peptidergic and nonpectidergic projections

Allelic Composition	Ret^tm1Ddg/Ret^tm1Ddg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Ret^tm1Ddg mutation (0 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:126484 )

• few mice survive beyond 3 weeks

digestive/alimentary system

aganglionic megacolon ( J:126484 )

• at P14

enlarged ileum ( J:126484 )

• at P14

abnormal jejunum morphology ( J:126484 )

• enlarged at P14

nervous system

abnormal neuron morphology ( J:126484 )

• at P14, non-peptidergic neurons are hypotrophic unlike in control Ret^tm1Ddg homozygotes

absent enteric neurons ( J:126484 )

• in the small intestine and colon

small dorsal root ganglion ( J:126484 )

• at P14, the dorsal root ganglia is 30% smaller than in control Ret^tm1Ddg homozygotes

behavior/neurological

weakness ( J:126484 )

• beginning at P3 mice develop progressive weakness

growth/size/body

distended abdomen ( J:126484 )

• at P3

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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