All Phenotypes Islr2<tm1.1Ddg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Islr2^tm1.1Ddg
targeted mutation 1.1, David D Ginty
MGI:4413447

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Islr2^tm1.1Ddg/Islr2^tm1.1Ddg	involves: 129S6/SvEvTac	MGI:5569797
hm2	Islr2^tm1.1Ddg/Islr2^tm1.1Ddg	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6	MGI:4413453
cn3	Islr2^tm1.1Ddg/Islr2^tm2.1Ddg Emx1^tm1(cre)Krj/Emx1⁺	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL	MGI:5569795
cn4	Islr2^tm1.1Ddg/Islr2^tm2.1Ddg Tg(mI56i-cre,EGFP)1Kc/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL	MGI:5569796
cx5	Bax^tm1Sjk/Bax^tm1Sjk Islr2^tm1.1Ddg/Islr2^tm1.1Ddg	involves: 129S6/SvEvTac * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:4413455
cx6	Islr2^tm1.1Ddg/Islr2^tm1.1Ddg Ret^tm1.1Ddg/Ret⁺	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6	MGI:4413451
cx7	Islr2^tm1.1Ddg/Islr2^tm1.1Ddg Ret^tm1.1Ddg/Ret^tm1.1Ddg	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6	MGI:4413452
cx8	Islr2^tm1.1Ddg/Islr2^tm1.1Ddg Tg(Hlxb9-GFP)1Tmj/0	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * CBA	MGI:4413454

Allelic Composition	Islr2^tm1.1Ddg/Islr2^tm1.1Ddg
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Islr2^tm1.1Ddg mutation (1 available); any Islr2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain morphology ( J:210221 )

• remnants of the descending component of the internal capsule are tangled within the striatum unlike in wild-type mice

• at E14.5 and E18.5, all thalamic projections fail to penetrate the diencephalic-telencephalic boundary and are misrouted into the ventral midbrain where they terminate entangled within the hypothalamus unlike in wild-type mice

• corticofugal axons fail to penetrate the pallial-subpallial boundary or extend within the subpallium unlike in wild-type mice

• however, the corpus callosum forms normally

absent brain internal capsule ( J:210221 )

• at E18.5 with a lack of thalamocortical projections

increased hippocampus pyramidal cell number ( J:210221 )

• slight increase in layer V pyramidal neurons in the cortex at P0

Allelic Composition	Islr2^tm1.1Ddg/Islr2^tm1.1Ddg
Genetic Background	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Islr2^tm1.1Ddg mutation (1 available); any Islr2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality ( J:154926 )

nervous system

abnormal neuron morphology ( J:154926 )

• at E12.5, peroneal and tibial nerves are shorter and thinner than in wild-type mice

• at E13.5, the common peroneal nerve is thinner than in wild-type mice

• at E13.5, superficial and deep branches of the common peroneal nerve are stalled unlike in wild-type mice with compensation from the sural and saphenous nerve that supplies branches to the regions normally innervated by the common peroneal nerve

• at E14.5, the length of the extension of the digital branch of the deep peroneal nerve into the third digit is 18% less than in wild-type mice

• the length of the lateral branch of the lateral plantar nerve in the fifth digit, a branch of the tibial nerve, is 9% shorter than in wild-type mice

• at E15.5, the number and order of branches in the medial digital branch of the lateral plantar nerve in the fifth digit are impaired compared to in wild-type mice

• the tibial nerve is underdeveloped compared to in wild-type mice

abnormal motor neuron morphology ( J:154926 )

• cultured lumbar motor neurons fail to exhibit or exhibit reduced GDNF-dependent axonal extension unlike similarly treated wild-type cells

abnormal neurite morphology ( J:154926 )

• in culture, NGF-induced axonal extension is reduced compared with similarly treated neurons from heterozygous mice

• cultured lumbar motor neurons fail to exhibit or exhibit reduced GDNF-dependent axonal extension unlike similarly treated wild-type cells

decreased neuron number ( J:154926 )

• at E15.5, mice have 16% fewer neurons in the dorsal root ganglion compared with wild-type mice

abnormal dorsal root ganglion morphology ( J:154926 )

• at E15.5, mice have 16% fewer neurons in the dorsal root ganglion compared with wild-type mice

behavior/neurological

abnormal sensory capabilities/reflexes/nociception ( J:154926 )

• mice fail to exhibit a response to a tail pinch unlike similarly treated wild-type mice

Allelic Composition	Islr2^tm1.1Ddg/Islr2^tm2.1Ddg Emx1^tm1(cre)Krj/Emx1⁺
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Islr2^tm1.1Ddg mutation (1 available); any Islr2 mutation (24 available)
Islr2^tm2.1Ddg mutation (1 available); any Islr2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:210221 )

• some mice die during the fourth postnatal week

nervous system

abnormal brain morphology ( J:210221 )

• hypoplastic thalamocortical projections

• few, if any, corticofugal and thalamocortical axons cross the pallial-subpallial boundary

• however, thalamocortical projections extension through the diencephalic-telencephalic boundary is normal

abnormal telencephalon development ( J:210221 )

• at P7, pallium and subpallium are almost completely disconnected

abnormal brain internal capsule morphology ( J:210221 )

• the main trunk is devoid of corticofugal axons

Allelic Composition	Islr2^tm1.1Ddg/Islr2^tm2.1Ddg Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Islr2^tm1.1Ddg mutation (1 available); any Islr2 mutation (24 available)
Islr2^tm2.1Ddg mutation (1 available); any Islr2 mutation (24 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:210221 )

• some mice die during the fourth postnatal week

nervous system

abnormal brain morphology ( J:210221 )

• thalamic projections are misrouted into the ventral midbrain and tangled within the hypothalamus and near complete absence of corticofugal and thalamocortical axons that cross the pallial-subpallial boundary unlike in wild-type mice

abnormal telencephalon development ( J:210221 )

• at P7, pallium and subpallium are nearly completely disconnected

abnormal brain internal capsule morphology ( J:210221 )

• disorganized with partially formed rostral part of the tract

decreased corticospinal tract size ( J:210221 )

• absent at P7

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Islr2^tm1.1Ddg/Islr2^tm1.1Ddg
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Islr2^tm1.1Ddg mutation (1 available); any Islr2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron morphology ( J:154926 )

• mice exhibit the same neuron defects observed in Islr2^tm1.1Ddg homozygotes

Allelic Composition	Islr2^tm1.1Ddg/Islr2^tm1.1Ddg Ret^tm1.1Ddg/Ret⁺
Genetic Background	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Islr2^tm1.1Ddg mutation (1 available); any Islr2 mutation (24 available)
Ret^tm1.1Ddg mutation (0 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron morphology ( J:154926 )

• the peroneal nerve is shorter than in wild-type mice and Islr2^tm1.1Ddg homozygotes

Allelic Composition	Islr2^tm1.1Ddg/Islr2^tm1.1Ddg Ret^tm1.1Ddg/Ret^tm1.1Ddg
Genetic Background	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron morphology ( J:154926 )

• the peroneal nerve is shorter than in wild-type mice and Islr2^tm1.1Ddg homozygotes

Allelic Composition	Islr2^tm1.1Ddg/Islr2^tm1.1Ddg Tg(Hlxb9-GFP)1Tmj/0
Genetic Background	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Islr2^tm1.1Ddg mutation (1 available); any Islr2 mutation (24 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:154926 )

• axons of the peroneal nerves are stalled compared to in wild-type mice

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