Allele Symbol Allele Name Allele ID |
Tcf7l1tm1.1Efu targeted mutation 1.1, Elaine Fuchs MGI:4413464 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• hair follicles appear but exhibit defects in subsequent down-growth compared to in wild-type mice
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• in skin grafts
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• newborn mice often lack whiskers unlike wild-type mice
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• basal cells are flattened unlike in wild-type mice
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• at P0, skin cells exhibit increased cell death compared to in wild-type mice
• grafted skin exhibits no hair and shrunk area without inflammation compared with wild-type skin grafts
• cultured skin epithelial fails to undergo long-term tissue maintenance unlike wild-type skin
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• cultured keratinocytes from P0 mice exhibit decreased proliferation compared with wild-type cells
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• cultured keratinocytes from P0 mice exhibit decreased proliferation compared with wild-type cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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