Phenotypes associated with this allele

• Allele Symbol: Grik4^tm1.1Sfh
• Allele Name: targeted mutation 1.1, Stephen F Heinemann
• Allele ID: MGI:4413475
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grik4^tm1.1Sfh/Grik4^tm1.1Sfh	involves: 129S4/SvJae	MGI:4413561
cx2	Grik4^tm1.1Sfh/Grik4^tm1.1Sfh Grik5^tm1Cont/Grik5^tm1Cont	involves: 129S/SvEv * 129S4/SvJae	MGI:4413560

Genotype
MGI:4413561

hm1

• Allelic Composition: Grik4^tm1.1Sfh/Grik4^tm1.1Sfh
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal excitatory postsynaptic currents ( J:155003 )

• following application with GYKI 53655, fewer cells exhibit lower GYKI-resistant excitatory postsynaptic currents than in similarly treated wild-type mice

• following application with GYKI 53655 and short trains of high-frequency stimulation, the amplitude of GYKI-resistant EPSC is reduced by half with slower deactivation kinetics compared to in similarly treated wild-type mice

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:155003 )

• following application with GYKI 53655, fewer cells exhibit lower GYKI-resistant excitatory postsynaptic currents than in similarly treated wild-type mice

• following application with GYKI 53655 and short trains of high-frequency stimulation, the amplitude of GYKI-resistant EPSC is reduced by half with slower deactivation kinetics compared to in similarly treated wild-type mice

Genotype
MGI:4413560

cx2

• Allelic Composition: Grik4^tm1.1Sfh/Grik4^tm1.1Sfh; Grik5^tm1Cont/Grik5^tm1Cont
• Genetic Background: involves: 129S/SvEv * 129S4/SvJae

nervous system

abnormal excitatory postsynaptic currents ( J:155003 )

• kainic acid fails to induce increases in excitatory postsynaptic current (EPSC) amplitudes unlike in similarly treated wild-type mice

• however, mice respond normally to high concentrations of kainic acid and kainate receptor-mediated inhibition of slow afterhyperpolarization current is normal

• following application with GYKI 53655, no cells exhibit GYKI-resistant EPSC unlike in similarly treated wild-type mice

• following application with GYKI 53655 and short trains of high-frequency stimulation, no GYKI-resistant EPSC is detected unlike in similarly treated wild-type mice

decreased paired-pulse facilitation ( J:155003 )

• at the shortest interstimulus interval, paired-pulse facilitation is impaired compared to in similarly treated wild-type mice

• however, frequency facilitation is intact

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:155003 )

• kainic acid fails to induce increases in excitatory postsynaptic current (EPSC) amplitudes unlike in similarly treated wild-type mice

• however, mice respond normally to high concentrations of kainic acid and kainate receptor-mediated inhibition of slow afterhyperpolarization current is normal

• following application with GYKI 53655, no cells exhibit GYKI-resistant EPSC unlike in similarly treated wild-type mice

• following application with GYKI 53655 and short trains of high-frequency stimulation, no GYKI-resistant EPSC is detected unlike in similarly treated wild-type mice