Analysis Tools|
Allele Symbol Allele Name Allele ID |
Clcn7tm3.1Tjj targeted mutation 3.1, Thomas J Jentsch MGI:4413670 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• degradation of the endocytosed protein in proximal tubule cells of the kidneys is disrupted compared to in wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike Clcn7tm2Tjj homozygotes, mice have a normal lifespan
|
|
• at 20 weeks in the cerebral cortex
|
|
• at 1.5 years of age, the cortex and hippocampus are almost completely degenerated unlike in wild-type mice
|
|
• at 20 weeks, the dentate gyrus exhibits conspicuous degeneration unlike in wild-type mice
• hippocampal structures are no longer detected by 1.5 years of age
|
|
• mice exhibit severe neuronal cell loss as early as 30 days after birth
|
|
• the cerebral cortex is reduced at 4 to 5 months of age
• at 1.5 years of age, the cortex and hippocampus are almost completely degenerated unlike in wild-type mice
|
|
• nearly all cortical neurons are lost by 1 year of age
|
|
• at 20 weeks in the cerebral cortex
|
|
• at 1.5 years of age, the cortex and hippocampus are almost completely degenerated unlike in wild-type mice
|
|
• progressive with severe neuronal cell loss as early as 30 days after birth
|
|
• at 4 to 5 months of age
|
|
• mice exhibit a lysosomal storage phenotype in the forebrain with altered Lamp-1 distribution compared to in wild-type mice
|
| N |
• unlike Clcn7tm2Tjj homozygotes, mice exhibit normal bone density
|
| N |
• unlike Clcn7tm2Tjj homozygotes, mice exhibit normal growth
|
|
• at 20 weeks in the cerebral cortex
|
|
• at 20 weeks in the cerebral cortex
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/10/2024 MGI 6.24 |
|
|
|
||
