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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ndptm1Lex
targeted mutation 1, Lexicon Genetics
MGI:4414644
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ndptm1Lex/Ndptm1Lex involves: 129S5/SvEvBrd MGI:4414648
cx2
 		Ndptm1Lex/Ndptm1Lex
Tspan12tm1Wye/Tspan12+ 		either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N) MGI:4414650
cx3
 		Ndptm1Lex/Y
Tspan12tm1Wye/Tspan12+ 		either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N) MGI:4414651
ot4
 		Ndptm1Lex/Y involves: 129S5/SvEvBrd MGI:4414649


Genotype
MGI:4414648
hm1
Allelic
Composition		 Ndptm1Lex/Ndptm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndptm1Lex mutation (0 available); any Ndp mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:154863 )
• retinal vasculature is extremely leaky and aberrant compared to in wild-type mice
• the inner and outer plexiform layers lack capillaries unlike in wild-type mice
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice
blood vessel congestion ( J:154863 )
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice
increased vascular permeability ( J:154863 )
• retinal vasculature is extremely leaky compared to in wild-type mice

vision/eye
abnormal retina vasculature morphology ( J:154863 )
• retinal vasculature is extremely leaky and aberrant compared to in wild-type mice
• the inner and outer plexiform layers lack capillaries unlike in wild-type mice
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice




Genotype
MGI:4414650
cx2
Allelic
Composition		 Ndptm1Lex/Ndptm1Lex
Tspan12tm1Wye/Tspan12+
Genetic
Background		 either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndptm1Lex mutation (0 available); any Ndp mutation (8 available)
Tspan12tm1Wye mutation (0 available); any Tspan12 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina vasculature morphology ( J:154863 )
• at P15 and P30, retinal vertical sprouts are reduced compared to in wild-type mice
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice

cardiovascular system
abnormal retina vasculature morphology ( J:154863 )
• at P15 and P30, retinal vertical sprouts are reduced compared to in wild-type mice
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice




Genotype
MGI:4414651
cx3
Allelic
Composition		 Ndptm1Lex/Y
Tspan12tm1Wye/Tspan12+
Genetic
Background		 either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndptm1Lex mutation (0 available); any Ndp mutation (8 available)
Tspan12tm1Wye mutation (0 available); any Tspan12 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina vasculature morphology ( J:154863 )
• at P15 and P30, retinal vertical sprouts are reduced compared to in wild-type mice
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice

cardiovascular system
abnormal retina vasculature morphology ( J:154863 )
• at P15 and P30, retinal vertical sprouts are reduced compared to in wild-type mice
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice




Genotype
MGI:4414649
ot4
Allelic
Composition		 Ndptm1Lex/Y
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndptm1Lex mutation (0 available); any Ndp mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:154863 )
• retinal vasculature is extremely leaky and aberrant compared to in wild-type mice
• the inner and outer plexiform layers lack capillaries unlike in wild-type mice
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice
blood vessel congestion ( J:154863 )
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice
increased vascular permeability ( J:154863 )
• retinal vasculature is extremely leaky compared to in wild-type mice

vision/eye
abnormal retina vasculature morphology ( J:154863 )
• retinal vasculature is extremely leaky and aberrant compared to in wild-type mice
• the inner and outer plexiform layers lack capillaries unlike in wild-type mice
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory