Phenotypes associated with this allele

• Allele Symbol: Il1rapl1^tm1.1Hesk
• Allele Name: targeted mutation 1.1, Henriette Skala
• Allele ID: MGI:4414655
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il1rapl1^tm1.1Hesk/Il1rapl1^tm1.1Hesk	involves: C57BL/6	MGI:4414659
ot2	Il1rapl1^tm1.1Hesk/Y	involves: C57BL/6	MGI:4414660

Genotype
MGI:4414659

hm1

• Allelic Composition: Il1rapl1^tm1.1Hesk/Il1rapl1^tm1.1Hesk
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal response to novelty ( J:293942 )

• reduced discrimination index in virtual object recognition test with stationary shapes

• normal behavior index in virtual object recognition test when presenting moving different shapes in intertrial delay

abnormal response to novel object ( J:293942 )

• reduced discrimination index in novel object recognition test

nervous system

nervous system phenotype ( J:155437 )

♀N • the cerebellar cortex is overall morphologically normal

abnormal cerebellar molecular layer ( J:155437 )

♀ • parallel fiber-mediated recruitment of molecular layer interneurons is increased compared to in wild-type mice as determined by higher feed-forward inhibition at mild stimulation

abnormal CNS synaptic transmission ( J:155437 )

♀ • for mild stimulation, mice exhibit higher feed-forward inhibition compared with similarly treated wild-type mice

♀ • mice exhibit disinhibition of deep cerebellar nuclei neurons compared with wild-type mice

abnormal inhibitory postsynaptic currents ( J:155437 )

♀ • between P10 and P12, the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) is decreased compared to in wild-type mice

♀ • giant sIPSCs occur at P10 without oversized synaptic contacts unlike in wild-type mice

♀ • however, the amplitudes of sIPSCs and frequencies of miniature IPSCs are normal

Genotype
MGI:4414660

ot2

• Allelic Composition: Il1rapl1^tm1.1Hesk/Y
• Genetic Background: involves: C57BL/6

nervous system

nervous system phenotype ( J:155437 )

♂N • the cerebellar cortex is overall morphologically normal

abnormal cerebellar molecular layer ( J:155437 )

♂ • parallel fiber-mediated recruitment of molecular layer interneurons is increased compared to in wild-type mice as determined by higher feed-forward inhibition at mild stimulation

abnormal CNS synaptic transmission ( J:155437 )

♂ • for mild stimulation, mice exhibit higher feed-forward inhibition compared with similarly treated wild-type mice

♂ • mice exhibit disinhibition of deep cerebellar nuclei neurons compared with wild-type mice

abnormal inhibitory postsynaptic currents ( J:155437 )

♂ • between P10 and P12, the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) is decreased compared to in wild-type mice

♂ • giant sIPSCs occur at P10 without oversized synaptic contacts unlike in wild-type mice

♂ • however, the amplitudes of sIPSCs and frequencies of miniature IPSCs are normal