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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrrk2tm1.1Cai
targeted mutation 1.1, Huaibin Cai
MGI:4414662
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lrrk2tm1.1Cai/Lrrk2tm1.1Cai involves: 129X1/SvJ * C57BL/6 MGI:4421008
hm2
 		Lrrk2tm1.1Cai/Lrrk2tm1.1Cai involves: 129X1/SvJ * C57BL/6J * FVB/N MGI:4414668
cx3
 		Lrrk2tm1.1Cai/Lrrk2+
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-SNCA*A53T)E2Cai/0 		involves: 129X1/SvJ * C57BL/6 MGI:4421006
cx4
 		Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-SNCA*A53T)E2Cai/0 		involves: 129X1/SvJ * C57BL/6 MGI:4421016


Genotype
MGI:4421008
hm1
Allelic
Composition		 Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrk2tm1.1Cai mutation (1 available); any Lrrk2 mutation (159 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:156512 )
N
• no elevated reactive astrocytosis, neurodegeneration or somatic accumulation of alpha-synuclein is observed in brains of 20-month old mice compared to controls; no aggregates of alpha-synuclein form in mutant brains
microgliosis ( J:156512 )
• a moderate increase in microglial activation is observed in the brains of 20-month old animals

cellular
accumulation of giant lysosomes in kidney/renal tubule cells ( J:314451 )
• late endosome/lysosomes are increased in size in the kidneys
abnormal vesicle-mediated transport ( J:314451 )
• mice show an accumulation of precursor and mature cathepsin D in the kidney, indicating trafficking defects and mis-sorting of lysosomal enzymes
abnormal Golgi vesicle transport ( J:314451 )
• mice show an increase in IGF2R (CI-M6PR), indicating less efficient cycling of CI-M6PR at the trans-Golgi network

renal/urinary system
accumulation of giant lysosomes in kidney/renal tubule cells ( J:314451 )
• late endosome/lysosomes are increased in size in the kidneys

immune system
microgliosis ( J:156512 )
• a moderate increase in microglial activation is observed in the brains of 20-month old animals

hematopoietic system
microgliosis ( J:156512 )
• a moderate increase in microglial activation is observed in the brains of 20-month old animals




Genotype
MGI:4414668
hm2
Allelic
Composition		 Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrk2tm1.1Cai mutation (1 available); any Lrrk2 mutation (159 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neurite morphology ( J:154755 )
• neurite length is increased compared to in wild-type mice
• total neurite outgrowth is increased compare to in wild-type mice
• however, the number of primary neurites is normal
abnormal axon morphology ( J:154755 )
• longer than in wild-type mice




Genotype
MGI:4421006
cx3
Allelic
Composition		 Lrrk2tm1.1Cai/Lrrk2+
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-SNCA*A53T)E2Cai/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrk2tm1.1Cai mutation (1 available); any Lrrk2 mutation (159 available)
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(tetO-SNCA*A53T)E2Cai mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system morphology ( J:156512 )
• somatic alpha synuclein in neurons is apparent at 12 months
microgliosis ( J:156512 )
• increased microglial activation is observed in the brain at 12 months
abnormal striatum morphology ( J:156512 )
• numbers of residual neurons is significantly lower than non transgenic controls
astrocytosis ( J:156512 )
• significant at 12 months
abnormal neuron morphology ( J:156512 )
• the Golgi complex shows severe fragmentation in 12 month old animals
neurodegeneration ( J:156512 )
• neurodegeneration significant at 12 months

immune system
microgliosis ( J:156512 )
• increased microglial activation is observed in the brain at 12 months

hematopoietic system
microgliosis ( J:156512 )
• increased microglial activation is observed in the brain at 12 months




Genotype
MGI:4421016
cx4
Allelic
Composition		 Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-SNCA*A53T)E2Cai/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrk2tm1.1Cai mutation (1 available); any Lrrk2 mutation (159 available)
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(tetO-SNCA*A53T)E2Cai mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:156512 )
N
• no apparent neurodegeneration is observed in 12-month old mice; no significant elevation of astrocytosis, microgliosis or somatic accumulation of alpha-synuclein is detected in striatum at 12 months




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory