All Phenotypes Gt(ROSA)26Sor<tm2(Gli2*)Flng> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gt(ROSA)26Sor^{tm2(Gli2*)Flng}
targeted mutation 2, Fanxin Long
MGI:4414671

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm2(Gli2*)Flng}/Gt(ROSA)26Sor⁺ Ihh^tm1Amc/Ihh^tm1Amc Tg(Col2a1-cre)3Amc/0	involves: 129S1/Sv * 129X1/SvJ	MGI:4414674
cn2	Gli3^Xt-J/Gli3^Xt-J Gt(ROSA)26Sor^{tm2(Gli2*)Flng}/Gt(ROSA)26Sor⁺ Ihh^tm1Amc/Ihh^tm1Amc Tg(Col2a1-cre)3Amc/0	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ	MGI:4414675
cn3	Gt(ROSA)26Sor^{tm2(Gli2*)Flng}/Gt(ROSA)26Sor⁺ Tg(Col2a1-cre)3Amc/0	involves: 129X1/SvJ	MGI:4414673
cx4	Gt(ROSA)26Sor^{tm2(Gli2*)Flng}/Gt(ROSA)26Sor⁺ Ihh^tm1Amc/Ihh^tm1Amc	involves: 129S1/Sv * 129X1/SvJ	MGI:4414677

Allelic Composition	Gt(ROSA)26Sor^{tm2(Gli2*)Flng}/Gt(ROSA)26Sor⁺ Ihh^tm1Amc/Ihh^tm1Amc Tg(Col2a1-cre)3Amc/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(Gli2*)Flng} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Ihh^tm1Amc mutation (1 available); any Ihh mutation (22 available)
Tg(Col2a1-cre)3Amc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:154905 )

• mice die at birth

skeleton

skeleton phenotype ( J:154905 )

N	• vascularization and bone formation in the diaphysis are normal

abnormal osteoblast differentiation ( J:154905 )

• similar to in Ihh^tm1Amc homozygotes, orthotopic osteoblast differentiation is impaired as determined by marker expression

abnormal long bone epiphyseal plate proliferative zone ( J:154905 )

• at E15.5 and E18.5, the proliferative zone is slightly larger than in Ihh^tm1Amc homozygotes but smaller than in wild-type mice

abnormal long bone hypertrophic chondrocyte zone ( J:154905 )

• vascularization of the hypertrophic zone is improved compared to in Ihh^tm1Amc homozygotes

disorganized long bone epiphyseal plate ( J:154905 )

• columnar organization of chondrocytes is partially restored compared to in Ihh^tm1Amc homozygotes but is still disorganized compared to in wild-type mice

abnormal perichondrium morphology ( J:154905 )

• at E18.5, mice fail to exhibit bone deposition in the perichondrium flanking the hypertrophic regions where the bone collar normally forms in the long bones of wild-type mice

cellular

abnormal osteoblast differentiation ( J:154905 )

• similar to in Ihh^tm1Amc homozygotes, orthotopic osteoblast differentiation is impaired as determined by marker expression

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J Gt(ROSA)26Sor^{tm2(Gli2*)Flng}/Gt(ROSA)26Sor⁺ Ihh^tm1Amc/Ihh^tm1Amc Tg(Col2a1-cre)3Amc/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (81 available)
Gt(ROSA)26Sor^{tm2(Gli2*)Flng} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Ihh^tm1Amc mutation (1 available); any Ihh mutation (22 available)
Tg(Col2a1-cre)3Amc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:154905 )

• mice die at birth

skeleton

skeleton phenotype ( J:154905 )

N	• unlike in Ihh^tm1Amc Gli3^Xt-J homozygotes the marrow cavity and hypertrophic chondrocyte are normal

abnormal long bone diaphysis morphology ( J:154905 )

• the growth region cartilage is longer than in wild-type mice

• the columnar zone contains areas of disorganization unlike in wild-type mice

• however, orthotopic bone collar formation is normal unlike in Ihh^tm1Amc homozygotes

growth/size/body

decreased body size ( J:154905 )

• while larger than Ihh^tm1Amc homozygotes at E18.5, mice are smaller than wild-type mice

limbs/digits/tail

short limbs ( J:154905 )

• while larger than in Ihh^tm1Amc homozygotes at E18.5, limbs are shorter than in wild-type mice

Allelic Composition	Gt(ROSA)26Sor^{tm2(Gli2*)Flng}/Gt(ROSA)26Sor⁺ Tg(Col2a1-cre)3Amc/0
Genetic Background	involves: 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased length of long bones ( J:154905 )

• 10% to 15% at E18.5

abnormal cartilage development ( J:154905 )

• as determined by marker expression, cartilage growth in long bones is reduced due to premature onset of hypertrophy compared with wild-type mice

abnormal long bone epiphyseal plate proliferative zone ( J:154905 )

• decreased at E14.5 and E18.5

decreased width of hypertrophic chondrocyte zone ( J:154905 )

• at E18.5

increased width of hypertrophic chondrocyte zone ( J:154905 )

• at E14.5

growth/size/body

decreased body size ( J:154905 )

Allelic Composition	Gt(ROSA)26Sor^{tm2(Gli2*)Flng}/Gt(ROSA)26Sor⁺ Ihh^tm1Amc/Ihh^tm1Amc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal osteoblast differentiation ( J:154905 )

• orthotopic osteoblast differentiation is impaired as determined by marker expression

abnormal long bone epiphyseal plate proliferative zone ( J:154905 )

• decreased at E18.5

abnormal long bone hypertrophic chondrocyte zone ( J:154905 )

• the hypertrophic zone lacks vascularization unlike in wild-type mice

disorganized long bone epiphyseal plate ( J:154905 )

• columnar organization prior to hypertrophy is absent unlike in wild-type mice

cellular

abnormal osteoblast differentiation ( J:154905 )

• orthotopic osteoblast differentiation is impaired as determined by marker expression

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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