Phenotypes associated with this allele

• Allele Symbol: Sptlc2^tm2.1Jia
• Allele Name: targeted mutation 2.1, Xian-cheng Jiang
• Allele ID: MGI:4414752
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sptlc2^tm2.1Jia/Sptlc2^tm2.1Jia	involves: 129S4/SvJaeSor * C57BL/6	MGI:4414754

Genotype
MGI:4414754

cn1

• Allelic Composition: Sptlc2^tm2.1Jia/Sptlc2^tm2.1Jia
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased cholesterol efflux ( J:155507 )

• following injection of adenovirus cre to induce liver-specific recombination, macrophage cholesterol efflux is increased 1.7-fold at 4 hours, and 2.3-fold at 8 hours compared with similarly treated wild-type cells

increased circulating cholesterol level ( J:155507 )

• following injection of adenovirus cre to induce liver-specific recombination, cholesterol serum levels are increased 19% for both HDL and non-HDL potions compared to in wild-type mice

increased circulating HDL cholesterol level ( J:155507 )

• following injection of adenovirus cre to induce liver-specific recombination

increased circulating phospholipid level ( J:155507 )

• following injection of adenovirus cre to induce liver-specific recombination, circulating phosphatidylcholine levels are increased 19% compared to in wild-type mice

abnormal sphingomyelin level ( J:155507 )

• following injection of adenovirus cre to induce liver-specific recombination, sphingomyelin serum levels are decreased 36% for both HDL and non-HDL potions compared to in wild-type mice

• following injection of adenovirus cre to induce liver-specific recombination, plasma ceramide levels are decreased 54% and sphingosine levels are increased 35% compared to in wild-type mice

• following injection of adenovirus cre to induce liver-specific recombination, sphingomyelin liver levels are decreased 38% for both HDL and non-HDL potions compared to in wild-type mice

• following injection of adenovirus cre to induce liver-specific recombination, liver ceramide levels are decreased 39% and sphingosine levels are increased 32%, and sphingo-1-phosphate levels are increased 38% compared to in wild-type mice

liver/biliary system

abnormal liver physiology ( J:155507 )

• following injection of adenovirus cre to induce liver-specific recombination, hepatocytes are less sensitive to lysenin-mediated cytolysis with an attenuated dose-dependent effect compared with wild-type cells

cellular

increased cholesterol efflux ( J:155507 )

• following injection of adenovirus cre to induce liver-specific recombination, macrophage cholesterol efflux is increased 1.7-fold at 4 hours, and 2.3-fold at 8 hours compared with similarly treated wild-type cells