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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rag1tm1.1Sadu
targeted mutation 1.1, Sandra Dueber
MGI:4414763
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rag1tm1.1Sadu/Rag1tm1.1Sadu involves: BALB/c MGI:4414768
cn2
 		Rag1tm1.1Sadu/Rag1tm1.1Sadu
Trdctm1Mal/Trdctm1Mal
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:5438822
cn3
 		Cd79atm2(cre/Esr1*)Reth/Cd79a+
Rag1tm1.1Sadu/Rag1tm1.1Sadu 		involves: BALB/c MGI:4414770
cx4
 		Cd79atm2(cre/Esr1*)Reth/Cd79a+
Rag1tm1.1Sadu/Rag1tm1.1Sadu 		involves: BALB/c MGI:4414769


Genotype
MGI:4414768
hm1
Allelic
Composition		 Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic
Background		 involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1.1Sadu mutation (0 available); any Rag1 mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:155473 )
• mice exhibit a block in B cell development and are indistinguishable from Rag1tm1Mom homozygotes with an accumulation of c-kit+B220+ Pre/Pre B cells and absence of IgM+ cells

immune system
arrested B cell differentiation ( J:155473 )
• mice exhibit a block in B cell development and are indistinguishable from Rag1tm1Mom homozygotes with an accumulation of c-kit+B220+ Pre/Pre B cells and absence of IgM+ cells




Genotype
MGI:5438822
cn2
Allelic
Composition		 Rag1tm1.1Sadu/Rag1tm1.1Sadu
Trdctm1Mal/Trdctm1Mal
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(cre/ERT2)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Rag1tm1.1Sadu mutation (0 available); any Rag1 mutation (123 available)
Trdctm1Mal mutation (1 available); any Trdc mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
small thymus ( J:187400 )
• in un-induced mice
• however, tamoxifen induction rescues thymus size
decreased gamma-delta T cell number ( J:187400 )
• Vgamma4+ gamma delta T cells in the peripheral lymph nodes, spleen, lung and liver despite tamoxifen treatment of adult mice
absent gamma-delta T cells ( J:187400 )
• absent IL17+ cells despite tamoxifen treatment of adult mice
increased gamma-delta T cell number ( J:187400 )
• Vgamma1+ gamma delta T cells in the spleen, lung and liver despite tamoxifen treatment of adult mice

hematopoietic system
small thymus ( J:187400 )
• in un-induced mice
• however, tamoxifen induction rescues thymus size
decreased gamma-delta T cell number ( J:187400 )
• Vgamma4+ gamma delta T cells in the peripheral lymph nodes, spleen, lung and liver despite tamoxifen treatment of adult mice
absent gamma-delta T cells ( J:187400 )
• absent IL17+ cells despite tamoxifen treatment of adult mice
increased gamma-delta T cell number ( J:187400 )
• Vgamma1+ gamma delta T cells in the spleen, lung and liver despite tamoxifen treatment of adult mice

endocrine/exocrine glands
small thymus ( J:187400 )
• in un-induced mice
• however, tamoxifen induction rescues thymus size




Genotype
MGI:4414770
cn3
Allelic
Composition		 Cd79atm2(cre/Esr1*)Reth/Cd79a+
Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic
Background		 involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm2(cre/Esr1*)Reth mutation (0 available); any Cd79a mutation (24 available)
Rag1tm1.1Sadu mutation (0 available); any Rag1 mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:155473 )
N
• following administration of tamoxifen, mice produce IgM+ cells, do not accumulate c-kit+B220+ Pre/Pre B cells, and produce B1-a cells




Genotype
MGI:4414769
cx4
Allelic
Composition		 Cd79atm2(cre/Esr1*)Reth/Cd79a+
Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic
Background		 involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm2(cre/Esr1*)Reth mutation (0 available); any Cd79a mutation (24 available)
Rag1tm1.1Sadu mutation (0 available); any Rag1 mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:155473 )
• mice exhibit a block in B cell development and are indistinguishable from Rag1tm1Mom homozygotes with an accumulation of c-kit+B220+ Pre/Pre B cells and absence of IgM+ cells

immune system
arrested B cell differentiation ( J:155473 )
• mice exhibit a block in B cell development and are indistinguishable from Rag1tm1Mom homozygotes with an accumulation of c-kit+B220+ Pre/Pre B cells and absence of IgM+ cells




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory