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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Ela-KRAS*G12D)9Eps
transgene insertion 9, Eric P Sandgren
MGI:4414765
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Ela-KRAS*G12D)9Eps/0
Tgfbr1tm1Bopa/Tgfbr1+ 		involves: 129S1/SvImJ * C57BL/6 * FVB MGI:5806470
cx2
 		Tg(Ela-KRAS*G12D)9Eps/0
Tgfbr1tm1Bopa/Tgfbr1+
Tg(Mt1-TGFBR2*)AM3Epb/0 		involves: 129S1/SvImJ * C57BL/6 * FVB MGI:5806471
cx3
 		Tg(Ela-KRAS*G12D)9Eps/0
Tg(Mt1-TGFBR2*)AM3Epb/0 		involves: C57BL/6 * FVB MGI:5806468
cx4
 		Mir216aem2Uf/Mir216aem2Uf
Tg(Ela-KRAS*G12D)9Eps/0 		involves: C57BL/6N * FVB MGI:6361645
cx5
 		Mir216aem1Uf/Mir216aem1Uf
Tg(Ela-KRAS*G12D)9Eps/0 		involves: C57BL/6N * FVB MGI:6361648
cx6
 		Mir217em2Uf/Mir217em2Uf
Tg(Ela-KRAS*G12D)9Eps/0 		involves: C57BL/6N * FVB MGI:6361636
cx7
 		Mir217em1Uf/Mir217em1Uf
Tg(Ela-KRAS*G12D)9Eps/0 		involves: C57BL/6N * FVB MGI:6361639
cx8
 		Mir216bem1Uf/Mir216bem1Uf
Tg(Ela-KRAS*G12D)9Eps/0 		involves: C57BL/6N * FVB MGI:6361642
tg9
 		Tg(Ela-KRAS*G12D)9Eps/0 involves: C57BL/6 * FVB MGI:5806467


Genotype
MGI:5806470
cx1
Allelic
Composition		 Tg(Ela-KRAS*G12D)9Eps/0
Tgfbr1tm1Bopa/Tgfbr1+
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ela-KRAS*G12D)9Eps mutation (0 available)
Tgfbr1tm1Bopa mutation (0 available); any Tgfbr1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased pancreas tumor incidence ( J:231759 )
• only 40% of mice present with neoplastic or metaplastic pancreatic lesions
abnormal pancreas physiology ( J:231759 )
• decrease in proliferating cell nuclear antigen (PCNA) staining throughout the entire pancreas

hematopoietic system
increased CD8-positive, alpha-beta T cell number ( J:231759 )
• expansion of CD8+ population in mesenteric lymph nodes
• total T-cell infiltration near pancreatic lesions is increased, with strong CD8+ infiltration but almost completely absent CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration, indicating a cytotoxic response against pancreatic lesions

immune system
increased CD8-positive, alpha-beta T cell number ( J:231759 )
• expansion of CD8+ population in mesenteric lymph nodes
• total T-cell infiltration near pancreatic lesions is increased, with strong CD8+ infiltration but almost completely absent CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration, indicating a cytotoxic response against pancreatic lesions

neoplasm
increased pancreas tumor incidence ( J:231759 )
• only 40% of mice present with neoplastic or metaplastic pancreatic lesions




Genotype
MGI:5806471
cx2
Allelic
Composition		 Tg(Ela-KRAS*G12D)9Eps/0
Tgfbr1tm1Bopa/Tgfbr1+
Tg(Mt1-TGFBR2*)AM3Epb/0
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ela-KRAS*G12D)9Eps mutation (0 available)
Tgfbr1tm1Bopa mutation (0 available); any Tgfbr1 mutation (36 available)
Tg(Mt1-TGFBR2*)AM3Epb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased gland tumor incidence ( J:231759 )
• mice are protected against pancreatic lesion formation

neoplasm
decreased gland tumor incidence ( J:231759 )
• mice are protected against pancreatic lesion formation




Genotype
MGI:5806468
cx3
Allelic
Composition		 Tg(Ela-KRAS*G12D)9Eps/0
Tg(Mt1-TGFBR2*)AM3Epb/0
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreas morphology ( J:231759 )
• expansion of the pancreatic stroma
increased pancreas tumor incidence ( J:231759 )
• mice show extensive intraductal papillary neoplasm development and associated parenchymal loss
pancreas fibrosis ( J:231759 )
• pancreatic lesions are accompanied with more severe fibrosis and heavy matrix deposition
pancreatic acinar-to-ductal metaplasia ( J:231759 )
• mice develop pancreatic acinar-to-ductal metaplasia
abnormal pancreas physiology ( J:231759 )
• increase in proliferating cell nuclear antigen (PCNA) staining throughout the entire pancreas
pancreas inflammation ( J:231759 )
• mice display marked pancreatic inflammation

hematopoietic system
increased regulatory T cell number ( J:231759 )
• total T-cell infiltration near pancreatic lesions is increased, with increased CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration but very little CD8+ infiltration

immune system
pancreas inflammation ( J:231759 )
• mice display marked pancreatic inflammation
increased regulatory T cell number ( J:231759 )
• total T-cell infiltration near pancreatic lesions is increased, with increased CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration but very little CD8+ infiltration

neoplasm
increased pancreas tumor incidence ( J:231759 )
• mice show extensive intraductal papillary neoplasm development and associated parenchymal loss

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
pancreatic carcinoma DOID:4905 OMIM:260350
 J:231759




Genotype
MGI:6361645
cx4
Allelic
Composition		 Mir216aem2Uf/Mir216aem2Uf
Tg(Ela-KRAS*G12D)9Eps/0
Genetic
Background		 involves: C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir216aem2Uf mutation (0 available); any Mir216a mutation (1 available)
Tg(Ela-KRAS*G12D)9Eps mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreas tumor incidence ( J:278847 )
• as in Tg(Ela-KRAS*G12D)9Eps mice

endocrine/exocrine glands
increased pancreas tumor incidence ( J:278847 )
• as in Tg(Ela-KRAS*G12D)9Eps mice




Genotype
MGI:6361648
cx5
Allelic
Composition		 Mir216aem1Uf/Mir216aem1Uf
Tg(Ela-KRAS*G12D)9Eps/0
Genetic
Background		 involves: C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir216aem1Uf mutation (0 available); any Mir216a mutation (1 available)
Tg(Ela-KRAS*G12D)9Eps mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreas tumor incidence ( J:278847 )
• as in Tg(Ela-KRAS*G12D)9Eps mice

endocrine/exocrine glands
increased pancreas tumor incidence ( J:278847 )
• as in Tg(Ela-KRAS*G12D)9Eps mice




Genotype
MGI:6361636
cx6
Allelic
Composition		 Mir217em2Uf/Mir217em2Uf
Tg(Ela-KRAS*G12D)9Eps/0
Genetic
Background		 involves: C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreas tumor incidence ( J:278847 )
• as in Tg(Ela-KRAS*G12D)9Eps mice

endocrine/exocrine glands
increased pancreas tumor incidence ( J:278847 )
• as in Tg(Ela-KRAS*G12D)9Eps mice




Genotype
MGI:6361639
cx7
Allelic
Composition		 Mir217em1Uf/Mir217em1Uf
Tg(Ela-KRAS*G12D)9Eps/0
Genetic
Background		 involves: C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreas tumor incidence ( J:278847 )
• as in Tg(Ela-KRAS*G12D)9Eps mice

endocrine/exocrine glands
increased pancreas tumor incidence ( J:278847 )
• as in Tg(Ela-KRAS*G12D)9Eps mice




Genotype
MGI:6361642
cx8
Allelic
Composition		 Mir216bem1Uf/Mir216bem1Uf
Tg(Ela-KRAS*G12D)9Eps/0
Genetic
Background		 involves: C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreas tumor incidence ( J:278847 )
• as in Tg(Ela-KRAS*G12D)9Eps mice

endocrine/exocrine glands
increased pancreas tumor incidence ( J:278847 )
• as in Tg(Ela-KRAS*G12D)9Eps mice




Genotype
MGI:5806467
tg9
Allelic
Composition		 Tg(Ela-KRAS*G12D)9Eps/0
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal pancreatic acinar cell morphology ( J:231759 )
• mice develop background mild acinar degeneration/pancreatitis after one year

endocrine/exocrine glands
abnormal pancreas morphology ( J:231759 )
• expansion of the pancreatic stroma
abnormal pancreatic acinar cell morphology ( J:231759 )
• mice develop background mild acinar degeneration/pancreatitis after one year
increased pancreas tumor incidence ( J:231759 )
• mice develop multiple intraductal papillary neoplasms after one year
pancreas degeneration ( J:231759 )
• mice present with mild pancreatic acinar degeneration at one year of age
pancreatic acinar-to-ductal metaplasia ( J:231759 )
• mice develop pancreatic acinar-to-ductal metaplasia after one year
pancreas inflammation ( J:231759 )
• mice develop background mild acinar degeneration/pancreatitis after one year

hematopoietic system
increased regulatory T cell number ( J:231759 )
• total T-cell infiltration near pancreatic lesions is increased, with increased CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration but very little CD8+ infiltration

immune system
pancreas inflammation ( J:231759 )
• mice develop background mild acinar degeneration/pancreatitis after one year
increased regulatory T cell number ( J:231759 )
• total T-cell infiltration near pancreatic lesions is increased, with increased CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration but very little CD8+ infiltration

neoplasm
increased pancreas tumor incidence ( J:231759 )
• mice develop multiple intraductal papillary neoplasms after one year




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory