Phenotypes associated with this allele

• Allele Symbol: Cldn7^tm1Yche
• Allele Name: targeted mutation 1, Yan-Hua Chen
• Allele ID: MGI:4414771
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cldn7^tm1Yche/Cldn7^tm1Yche	involves: C57BL/6	MGI:4414772

Genotype
MGI:4414772

hm1

• Allelic Composition: Cldn7^tm1Yche/Cldn7^tm1Yche
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:155363 )

• mice die by P12

renal/urinary system

abnormal urine homeostasis ( J:155363 )

• at P7, urine levels and fractional excretion of potassium, chloride, and sodium ion are increased compared to in wild-type mice

• however, urine magnesium and calcium levels are normal

increased urine chloride ion level ( J:155363 )

increased urine potassium level ( J:155363 )

• at P7

increased urine sodium level ( J:155363 )

• at P7

abnormal kidney morphology ( J:155363 )

• some mice exhibit hydropic changes in the kidneys and detached tubular epithelial cells later in their lives unlike wild-type mice

growth/size/body

decreased body size ( J:155363 )

• beginning at P4 and P5

decreased body weight ( J:155363 )

• at 1 week, body weight is 36% of wild-type mice

decreased body length ( J:155363 )

• at 1 week, body length is 65% of wild-type mice

postnatal growth retardation ( J:155363 )

• mice exhibit growth retardation and a failure to thrive compared with wild-type mice

homeostasis/metabolism

increased blood urea nitrogen level ( J:155363 )

• 70% at P7

increased circulating aldosterone level ( J:155363 )

• at P4 and P7

dehydration ( J:155363 )

• mice exhibit chronic dehydration without a change in transepidermal water loss

abnormal urine homeostasis ( J:155363 )

• at P7, urine levels and fractional excretion of potassium, chloride, and sodium ion are increased compared to in wild-type mice

• however, urine magnesium and calcium levels are normal

increased urine chloride ion level ( J:155363 )

increased urine potassium level ( J:155363 )

• at P7

increased urine sodium level ( J:155363 )

• at P7

hematopoietic system

increased hematocrit ( J:155363 )

• at P7

integument

wrinkled skin ( J:155363 )

• at 1 week