Phenotypes associated with this allele

• Allele Symbol: Grin2a^tm1.1Tnkw
• Allele Name: targeted mutation 1.1, Takanobu Nakazawa
• Allele ID: MGI:4414793
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin2a^tm1.1Tnkw/Grin2a^tm1.1Tnkw	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:4414795

Genotype
MGI:4414795

hm1

• Allelic Composition: Grin2a^tm1.1Tnkw/Grin2a^tm1.1Tnkw
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:155360 )

N • mice exhibit normal spontaneous activity, fear conditioning, spatial working memory, acoustic startle response, pre-pulse inhibition, and responses to tail flick and hot plate

abnormal depression-related behavior ( J:155360 )

• when suspended by their tail or forced to swim, mice are less immobile than wild-type mice

nervous system

nervous system phenotype ( J:155360 )

N • mice exhibit normal monoamine systems

abnormal excitatory postsynaptic currents ( J:155360 )

• NMDA-mediated excitatory postsynaptic current is not potentiated by Src unlike in similarly treated wild-type mice

reduced NMDA-mediated synaptic currents ( J:155360 )

• NMDA-mediated excitatory postsynaptic current is not potentiated by Src unlike in similarly treated wild-type mice