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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ndptm2Nat
targeted mutation 2, Jeremy Nathans
MGI:4414794
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ndptm2Nat/Ndp+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4412193


Genotype
MGI:4412193
ht1
Allelic
Composition		 Ndptm2Nat/Ndp+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndptm2Nat mutation (1 available); any Ndp mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina vasculature morphology ( J:154020 )
• vascular development on the vitreal face of the retina is retarded
• retinal mural cells are thinner and lower in density than in controls

nervous system
abnormal brain vasculature morphology ( J:154020 )
• progressive reduction in vascular density in the cerebellum

cardiovascular system
abnormal brain vasculature morphology ( J:154020 )
• progressive reduction in vascular density in the cerebellum
abnormal retina vasculature morphology ( J:154020 )
• vascular development on the vitreal face of the retina is retarded
• retinal mural cells are thinner and lower in density than in controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory