normal phenotype
• viable, fertile and phenotypically indistinguishable from wild-type littermates
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Allele Symbol Allele Name Allele ID |
Stk3tm1Dlim targeted mutation 1, Dae-Sik Lim MGI:4414809 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• viable, fertile and phenotypically indistinguishable from wild-type littermates
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• die between E8.5 and E9.5
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• collapse of the yolk sac vasculature by E9.5
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• in the embryonic tissue E8.5 and E9.5
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• at E8.5
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• deformed at E8.5
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• at E9.5
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• detectable by E8.5, overt by E9.5
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• at E8.5
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• at E8.5 - E9.0, the neural plate fails to fuse to form the neural tube and is kinked dorsoventrally
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• disorganized at E9.5 without any obvious boundary in the forebrain region and with a disorganized accumulation of neuroepithelial cells
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• expression analysis suggests a decrease in the number of trophoblast giant cells
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• suggested by expression analysis
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• expression analysis suggests a decrease in the number of chorion cells
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• formation of the labyrinth layer is severely disrupted
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• vasculature is sparse and contains few embryonic erythrocytes
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• yolk sacs appear to have reduced numbers of hematopoietic cells at E9.5
• cells from E8.5 yolk sacs form fewer hematopoietic colonies in culture compared to controls
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• while chorioallantoic fusion is normal formation of the labyrinth layer and all subsequent developmental steps are severely disrupted
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• transport of rhodamine dye across the placenta is reduced
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• at E8.5 - E9.0, the neural plate fails to fuse to form the neural tube and is kinked dorsoventrally
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• disorganized at E9.5 without any obvious boundary in the forebrain region and with a disorganized accumulation of neuroepithelial cells
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• total vascularity is decreased at E9.5
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• at E9.5
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• vasculature is sparse and contains few embryonic erythrocytes
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• at E9.5 the dorsal aorta has only primitive vasculature and the somites lack small sprouting vessels
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• impaired
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• collapse of the yolk sac vasculature by E9.5
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• severe developmental retardation of the endocardium is detected at E9.5
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• in the embryonic tissue E8.5 and E9.5
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• at E8.5
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• disruption of the spatiotemporal pattern of cell proliferation in the embryonic tissue at E9.0 and E9.5
• however, no change in the number of proliferating cells is detected
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• yolk sacs appear to have reduced numbers of hematopoietic cells at E9.5
• cells from E8.5 yolk sacs form fewer hematopoietic colonies in culture compared to controls
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• detectable by E8.5, overt by E9.5
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• at E8.5
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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