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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Stk3tm1Dlim
targeted mutation 1, Dae-Sik Lim
MGI:4414809
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Stk3tm1Dlim/Stk3tm1Dlim Not Specified MGI:4414820
cx2
Stk3tm1Dlim/Stk3tm1Dlim
Stk4tm1Dlim/Stk4tm1Dlim
Not Specified MGI:4414821


Genotype
MGI:4414820
hm1
Allelic
Composition
Stk3tm1Dlim/Stk3tm1Dlim
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1Dlim mutation (0 available); any Stk3 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• viable, fertile and phenotypically indistinguishable from wild-type littermates




Genotype
MGI:4414821
cx2
Allelic
Composition
Stk3tm1Dlim/Stk3tm1Dlim
Stk4tm1Dlim/Stk4tm1Dlim
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1Dlim mutation (0 available); any Stk3 mutation (49 available)
Stk4tm1Dlim mutation (0 available); any Stk4 mutation (74 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• collapse of the yolk sac vasculature by E9.5
• in the embryonic tissue E8.5 and E9.5
• deformed at E8.5
• detectable by E8.5, overt by E9.5
• at E8.5 - E9.0, the neural plate fails to fuse to form the neural tube and is kinked dorsoventrally
• disorganized at E9.5 without any obvious boundary in the forebrain region and with a disorganized accumulation of neuroepithelial cells
• expression analysis suggests a decrease in the number of trophoblast giant cells
• suggested by expression analysis
• expression analysis suggests a decrease in the number of chorion cells
• formation of the labyrinth layer is severely disrupted
• vasculature is sparse and contains few embryonic erythrocytes
• yolk sacs appear to have reduced numbers of hematopoietic cells at E9.5
• cells from E8.5 yolk sacs form fewer hematopoietic colonies in culture compared to controls
• while chorioallantoic fusion is normal formation of the labyrinth layer and all subsequent developmental steps are severely disrupted
• transport of rhodamine dye across the placenta is reduced

nervous system
• at E8.5 - E9.0, the neural plate fails to fuse to form the neural tube and is kinked dorsoventrally
• disorganized at E9.5 without any obvious boundary in the forebrain region and with a disorganized accumulation of neuroepithelial cells

cardiovascular system
• total vascularity is decreased at E9.5
• vasculature is sparse and contains few embryonic erythrocytes
• at E9.5 the dorsal aorta has only primitive vasculature and the somites lack small sprouting vessels
• collapse of the yolk sac vasculature by E9.5
• severe developmental retardation of the endocardium is detected at E9.5

cellular
• in the embryonic tissue E8.5 and E9.5
• disruption of the spatiotemporal pattern of cell proliferation in the embryonic tissue at E9.0 and E9.5
• however, no change in the number of proliferating cells is detected

hematopoietic system
• yolk sacs appear to have reduced numbers of hematopoietic cells at E9.5
• cells from E8.5 yolk sacs form fewer hematopoietic colonies in culture compared to controls

growth/size/body
• detectable by E8.5, overt by E9.5





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory