Analysis Tools
reproductive system
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• homozygous mice mated to homozygous mice produce embryos that die prior to E8.5
• homozygous mice mated to homozygous mice produce embryos that when extracted at E2.5 and cultured develop slower than wild-type mice
• however, female mice exhibit normal angiogenic-related processes during pregnancy and both female and male mice exhibit expected litter survival when mated to wild-type mice or Ate1tm1Akas homozygotes
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• 2 pups per litter comapred to 7 pups per litter for Ate1tm2.1Akas Tg(Tek-cre)12Flv heterozygotes
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