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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Elavl1tm1.1Thla
targeted mutation 1.1, Timothy Hla
MGI:4414854
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Elavl1tm1.1Thla/Elavl1tm1.1Thla involves: 129S1/Sv MGI:4414938
ht2
 		Elavl1tm1.1Thla/Elavl1+ involves: 129S1/Sv MGI:4414939


Genotype
MGI:4414938
hm1
Allelic
Composition		 Elavl1tm1.1Thla/Elavl1tm1.1Thla
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl1tm1.1Thla mutation (0 available); any Elavl1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:155109 )
• no live-born mice are obtained (no time of death given)




Genotype
MGI:4414939
ht2
Allelic
Composition		 Elavl1tm1.1Thla/Elavl1+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl1tm1.1Thla mutation (0 available); any Elavl1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Elavl1tm1.1Thla/Elavl1+ mice have increased sensitivity to whole-body irradiation

hematopoietic system
thymus hypoplasia ( J:155109 )
• following whole-body gamma irradiation, mice exhibit a more drastic decrease in cellularity in the bone marrow, spleen, and thymus compared to similarly treated wild-type mice
decreased bone marrow cell number ( J:155109 )
• following whole-body gamma irradiation, mice exhibit a more drastic decrease in cellularity in the bone marrow, spleen, and thymus compared to similarly treated wild-type mice
spleen hypoplasia ( J:155109 )
• following whole-body gamma irradiation, mice exhibit a more drastic decrease in cellularity in the bone marrow, spleen, and thymus compared to similarly treated wild-type mice

cellular
increased cellular sensitivity to gamma-irradiation ( J:155109 )
• following whole-body gamma irradiation, mice exhibit a more drastic decrease in cellularity in the bone marrow, spleen, and thymus compared to similarly treated wild-type mice

immune system
thymus hypoplasia ( J:155109 )
• following whole-body gamma irradiation, mice exhibit a more drastic decrease in cellularity in the bone marrow, spleen, and thymus compared to similarly treated wild-type mice
spleen hypoplasia ( J:155109 )
• following whole-body gamma irradiation, mice exhibit a more drastic decrease in cellularity in the bone marrow, spleen, and thymus compared to similarly treated wild-type mice

endocrine/exocrine glands
thymus hypoplasia ( J:155109 )
• following whole-body gamma irradiation, mice exhibit a more drastic decrease in cellularity in the bone marrow, spleen, and thymus compared to similarly treated wild-type mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory