All Phenotypes Tg(S100A8-cre,-EGFP)1Ilw MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Syk^tm1Tyb/Syk^tm1.2Tara Tg(S100A8-cre,-EGFP)1Ilw/0	involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6	MGI:4415251
cn2	Gt(ROSA)26Sor^{tm1(OVAL/fla,GFP)Vnce}/Gt(ROSA)26Sor⁺ Tg(S100A8-cre,-EGFP)1Ilw/0	involves: C3H * C57BL/6 * C57BL/6J	MGI:6196860

Allelic Composition	Syk^tm1Tyb/Syk^tm1.2Tara Tg(S100A8-cre,-EGFP)1Ilw/0
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syk^tm1.2Tara mutation (1 available); any Syk mutation (42 available)
Syk^tm1Tyb mutation (0 available); any Syk mutation (42 available)
Tg(S100A8-cre,-EGFP)1Ilw mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired granulocyte bactericidal activity ( J:155479 )

• S. aureus-infected mice exhibit a 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice

hematopoietic system

impaired granulocyte bactericidal activity ( J:155479 )

• S. aureus-infected mice exhibit a 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:260047 )

• mice are runted

decreased body weight ( J:260047 )

• mice treated with an alpha IL-1R blocking antibody show weight gain

hematopoietic system

increased neutrophil cell number ( J:260047 )

• increase in neutrophils in the spleen and lymph nodes

increased monocyte cell number ( J:260047 )

• increase in monocytes in the spleen and lymph nodes

homeostasis/metabolism

abnormal circulating cytokine level ( J:260047 )

• mice exhibit increased cytokine levels, with IL-18 having the greatest increase

increased circulating interleukin-18 level ( J:260047 )

joint swelling ( J:260047 )

• mice develop joint swelling

• mice treated with an alpha IL-1R blocking antibody show deceased joint swelling