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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Syktm1.2Tara
targeted mutation 1.2, Alexander Tarakhovsky
MGI:4415245
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Syktm1.2Tara/Syktm1.2Tara
Tg(Cr2-cre)3Cgn/0
involves: 129P2/OlaHsd MGI:5568508
cn2
Itgamtm1Myd/Itgamtm1Myd
Syktm1Tyb/Syktm1.2Tara
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6 MGI:4415250
cn3
Syktm1Tyb/Syktm1.2Tara
Tg(S100A8-cre,-EGFP)1Ilw/0
involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6 MGI:4415251
cn4
Syktm1Tyb/Syktm1.2Tara
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:4415249
cn5
Syktm1.2Tara/Syktm1.2Tara
Tg(Itgax-cre)1-1Reiz/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5314240


Genotype
MGI:5568508
cn1
Allelic
Composition
Syktm1.2Tara/Syktm1.2Tara
Tg(Cr2-cre)3Cgn/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syktm1.2Tara mutation (1 available); any Syk mutation (42 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mature B cells exhibit a follicular B cell-like phenotype

immune system
• mature B cells exhibit a follicular B cell-like phenotype




Genotype
MGI:4415250
cn2
Allelic
Composition
Itgamtm1Myd/Itgamtm1Myd
Syktm1Tyb/Syktm1.2Tara
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgamtm1Myd mutation (1 available); any Itgam mutation (48 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Syktm1.2Tara mutation (1 available); any Syk mutation (42 available)
Syktm1Tyb mutation (0 available); any Syk mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• S. aureus-infected mice exhibit an increased in viable S. aureus compared to in similarly treated wild-type mice

hematopoietic system
• S. aureus-infected mice exhibit an increased in viable S. aureus compared to in similarly treated wild-type mice




Genotype
MGI:4415251
cn3
Allelic
Composition
Syktm1Tyb/Syktm1.2Tara
Tg(S100A8-cre,-EGFP)1Ilw/0
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syktm1.2Tara mutation (1 available); any Syk mutation (42 available)
Syktm1Tyb mutation (0 available); any Syk mutation (42 available)
Tg(S100A8-cre,-EGFP)1Ilw mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• S. aureus-infected mice exhibit a 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice

hematopoietic system
• S. aureus-infected mice exhibit a 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice




Genotype
MGI:4415249
cn4
Allelic
Composition
Syktm1Tyb/Syktm1.2Tara
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Syktm1.2Tara mutation (1 available); any Syk mutation (42 available)
Syktm1Tyb mutation (0 available); any Syk mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• migration of neutrophils to the cite of bacterial infection is enhanced compared to in similarly treated wild-type mice
• S. aureus-infected mice exhibit a 3- to 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice

hematopoietic system
• migration of neutrophils to the cite of bacterial infection is enhanced compared to in similarly treated wild-type mice
• S. aureus-infected mice exhibit a 3- to 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice




Genotype
MGI:5314240
cn5
Allelic
Composition
Syktm1.2Tara/Syktm1.2Tara
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syktm1.2Tara mutation (1 available); any Syk mutation (42 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit normal perinatal survival

immune system
N
• mice exhibit normal lymphatic vessels

homeostasis/metabolism
N
• mice do not exhibit edema





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory