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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cacna1atm1Nobs
targeted mutation 1, Noboru Suzuki
MGI:4415271
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cacna1atm1Nobs/Cacna1atm1Nobs involves: 129 * C57BL/6J MGI:4415278
ht2
 		Cacna1atm1Nobs/Cacna1atm2Nobs involves: 129 * C57BL/6J MGI:4415280


Genotype
MGI:4415278
hm1
Allelic
Composition		 Cacna1atm1Nobs/Cacna1atm1Nobs
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1atm1Nobs mutation (0 available); any Cacna1a mutation (118 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

behavior/neurological
abnormal motor capabilities/coordination/movement ( J:155607 )
• mice exhibit severe paroxysmal dyskinesia
ataxia ( J:155607 )
• severe




Genotype
MGI:4415280
ht2
Allelic
Composition		 Cacna1atm1Nobs/Cacna1atm2Nobs
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1atm1Nobs mutation (0 available); any Cacna1a mutation (118 available)
Cacna1atm2Nobs mutation (0 available); any Cacna1a mutation (118 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:155607 )
• mice die at around 3 weeks of age

nervous system

behavior/neurological
abnormal motor capabilities/coordination/movement ( J:155607 )
• mice exhibit paroxysmal dyskinesia
ataxia ( J:155607 )
• at 10 to 12 days




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory