Phenotypes associated with this allele

• Allele Symbol: Cacna1a^tm1Nobs
• Allele Name: targeted mutation 1, Noboru Suzuki
• Allele ID: MGI:4415271
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna1a^tm1Nobs/Cacna1a^tm1Nobs	involves: 129 * C57BL/6J	MGI:4415278
ht2	Cacna1a^tm1Nobs/Cacna1a^tm2Nobs	involves: 129 * C57BL/6J	MGI:4415280

Genotype
MGI:4415278

hm1

• Allelic Composition: Cacna1a^tm1Nobs/Cacna1a^tm1Nobs
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:155607 )

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:155607 )

• mice exhibit severe paroxysmal dyskinesia

ataxia ( J:155607 )

• severe

Genotype
MGI:4415280

ht2

• Allelic Composition: Cacna1a^tm1Nobs/Cacna1a^tm2Nobs
• Genetic Background: involves: 129 * C57BL/6J

mortality/aging

postnatal lethality, complete penetrance ( J:155607 )

• mice die at around 3 weeks of age

nervous system

absence seizures ( J:155607 )

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:155607 )

• mice exhibit paroxysmal dyskinesia

ataxia ( J:155607 )

• at 10 to 12 days

absence seizures ( J:155607 )