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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Etv5tm1Hass
targeted mutation 1, John Hassell
MGI:4415294
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Etv5tm1Hass/Etv5tm1Hass involves: 129S1/Sv MGI:4415301
cx2
 		Etv4tm1Arbr/Etv4+
Etv5tm1Hass/Etv5+ 		involves: 129S1/Sv MGI:4415302
cx3
 		Etv4tm1Arbr/Etv4tm1Arbr
Etv5tm1Hass/Etv5+ 		involves: 129S1/Sv MGI:4415304
cx4
 		Etv4tm1Arbr/Etv4tm1Arbr
Etv5tm1Hass/Etv5+
Tg(Hoxb7-Venus*)17Cos/0 		involves: 129S1/Sv * C57BL/6J * CBA/J MGI:4415622


Genotype
MGI:4415301
hm1
Allelic
Composition		 Etv5tm1Hass/Etv5tm1Hass
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv5tm1Hass mutation (0 available); any Etv5 mutation (271 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:155594 )
• mice die prior to kidney development




Genotype
MGI:4415302
cx2
Allelic
Composition		 Etv4tm1Arbr/Etv4+
Etv5tm1Hass/Etv5+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4tm1Arbr mutation (0 available); any Etv4 mutation (41 available)
Etv5tm1Hass mutation (0 available); any Etv5 mutation (271 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal hypoplasia ( J:155594 )
• in 15% of mice
absent kidney ( J:155594 )
• in 8% of mice




Genotype
MGI:4415304
cx3
Allelic
Composition		 Etv4tm1Arbr/Etv4tm1Arbr
Etv5tm1Hass/Etv5+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4tm1Arbr mutation (0 available); any Etv4 mutation (41 available)
Etv5tm1Hass mutation (0 available); any Etv5 mutation (271 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal kidney morphology ( J:155594 )
• hypoplastic kidneys are small and cystic, lack nephrogenic zone and have greatly reduced tubular elements and glomeruli compared to in wild-type mice
renal hypoplasia ( J:155594 )
• in 52% of mice
abnormal nephron morphology ( J:155594 )
• kidneys lack the nephorgenic zone
absent kidney ( J:155594 )
• in 41% of mice
absent ureter ( J:155594 )
• in 22% of mice

growth/size/body
kidney cyst ( J:155594 )




Genotype
MGI:4415622
cx4
Allelic
Composition		 Etv4tm1Arbr/Etv4tm1Arbr
Etv5tm1Hass/Etv5+
Tg(Hoxb7-Venus*)17Cos/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4tm1Arbr mutation (0 available); any Etv4 mutation (41 available)
Etv5tm1Hass mutation (0 available); any Etv5 mutation (271 available)
Tg(Hoxb7-Venus*)17Cos mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
absent kidney ( J:155594 )
• in most mice
abnormal ureter development ( J:155594 )
• at E11.5 to E12.5, 16% of ureteric buds are absent, 40% show no branching, 19% exhibit retarded branching compared to in wild-type mice
• when kidneys form they contain reduced numbers and irregularly patterned ureteric bud tips unlike in wild-type mice
• cultured ureteric buds fail to develop unlike wild-type samples and samples containing only one to two mutant alleles




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory