About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Xcl1tm1Rakr
targeted mutation 1, Richard A Kroczek
MGI:4415308
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Xcl1tm1Rakr/Xcl1tm1Rakr B6.129-Xcl1tm1Rakr MGI:4415312
cx2
 		Xcl1tm1Rakr/Xcl1tm1Rakr
Tg(TcraTcrb)1100Mjb/0 		involves: 129/Sv * C57BL/6 MGI:4415311


Genotype
MGI:4415312
hm1
Allelic
Composition		 Xcl1tm1Rakr/Xcl1tm1Rakr
Genetic
Background		 B6.129-Xcl1tm1Rakr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xcl1tm1Rakr mutation (0 available); any Xcl1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:155297 )
N
• mice exhibit normal immune cell composition
decreased cytotoxic T cell cytolysis ( J:155297 )
• day 21 after immunization with ovalbumin

hematopoietic system
decreased cytotoxic T cell cytolysis ( J:155297 )
• day 21 after immunization with ovalbumin




Genotype
MGI:4415311
cx2
Allelic
Composition		 Xcl1tm1Rakr/Xcl1tm1Rakr
Tg(TcraTcrb)1100Mjb/0
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraTcrb)1100Mjb mutation (6 available)
Xcl1tm1Rakr mutation (0 available); any Xcl1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell number ( J:155297 )
• 12 days after immunization in an adoptive transfer experiment, the number of T cells in the spleen, lymph nodes, lung, liver, and bone marrow are reduced compared with wild-type cells
abnormal CD8-positive, alpha-beta T cell physiology ( J:155297 )
• fewer CD8+ T cells respond to antigen-cross presentation by CD8+ dendritic cells compared to in wild-type mice
decreased cytotoxic T cell cytolysis ( J:155297 )
• 12 days after immunization in adoptive transfer experiments
decreased interferon-gamma secretion ( J:155297 )
• immunized T cells produce less IFN-gamma on day 12 compared with similarly treated wild-type cells

hematopoietic system
decreased T cell number ( J:155297 )
• 12 days after immunization in an adoptive transfer experiment, the number of T cells in the spleen, lymph nodes, lung, liver, and bone marrow are reduced compared with wild-type cells
abnormal CD8-positive, alpha-beta T cell physiology ( J:155297 )
• fewer CD8+ T cells respond to antigen-cross presentation by CD8+ dendritic cells compared to in wild-type mice
decreased cytotoxic T cell cytolysis ( J:155297 )
• 12 days after immunization in adoptive transfer experiments




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory