Phenotypes associated with this allele

• Allele Symbol: Kif26a^tm1.1Noh
• Allele Name: targeted mutation 1.1, Nobutaka Hirokawa
• Allele ID: MGI:4415314
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kif26a^tm1.1Noh/Kif26a^tm1.1Noh	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J	MGI:4415326

Genotype
MGI:4415326

hm1

• Allelic Composition: Kif26a^tm1.1Noh/Kif26a^tm1.1Noh
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:154859 )

• mice die within 5 weeks of birth

postnatal lethality, incomplete penetrance ( J:154859 )

• median life span is 15 days

• mean life span is 16 days

digestive/alimentary system

digestive/alimentary phenotype ( J:154859 )

N • mice exhibit normal smooth muscle and Cajal cells in the colon

abnormal colon morphology ( J:154859 )

• mice exhibit severe occlusion of the distal colon

megacolon ( J:154859 )

• from the distal small intestine to the proximal colon

abnormal intestinal peristalsis ( J:154859 )

• carbachol-stimulated mice exhibit uncoordinated colon motility compared with similarly treated wild-type mice

nervous system

abnormal axon extension ( J:154859 )

• enteric neurite lengths are shorter than in wild-type mice

abnormal neuronal precursor proliferation ( J:154859 )

• between E11.5 and E13.5, proliferation of enteric nervous system precursors is increased compared to in wild-type mice

abnormal enteric ganglia morphology ( J:154859 )

• mice exhibit hyperganglionosis in the distal colon compared with wild-type mice

• between E11.5 and E13.5, proliferation of enteric nervous system precursors is increased compared to in wild-type mice

• enteric ganglia are less interconnected by acetylcholinesterase+ and nicotinamide adenine dinucleotide phosphate disphorase+ fibers than in wild-type mice

abnormal enteric neuron morphology ( J:154859 )

• the number of acetylcholinesterase+ and nicotinamide adenine dinucleotide phosphate disphorase+ neurons in the distal colon and to a lesser extent the proximal colon is increased compared to in wild-type mice

• enteric neurite lengths are shorter than in wild-type mice

growth/size/body

cachexia ( J:154859 )

• mice become emaciated

postnatal growth retardation ( J:154859 )

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:154859 )

• carbachol-stimulated mice exhibit uncoordinated colon motility compared with similarly treated wild-type mice

cellular

abnormal axon extension ( J:154859 )

• enteric neurite lengths are shorter than in wild-type mice

abnormal neuronal precursor proliferation ( J:154859 )

• between E11.5 and E13.5, proliferation of enteric nervous system precursors is increased compared to in wild-type mice

muscle

abnormal intestinal peristalsis ( J:154859 )

• carbachol-stimulated mice exhibit uncoordinated colon motility compared with similarly treated wild-type mice