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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Icostm1.1Wks
targeted mutation 1.1, Woong-Kyung Suh
MGI:4415349
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Icostm1.1Wks/Icostm1.1Wks involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4415351


Genotype
MGI:4415351
hm1
Allelic
Composition
Icostm1.1Wks/Icostm1.1Wks
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icostm1.1Wks mutation (0 available); any Icos mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• upon immunization
• drastic reduction in the percentage of germinal B cells relative to the total number of B cells
• percentage of TFH (CXCR5+, ICOS+) cells reduced by 5- to 9-fold in the Peyer's patch and spleen
• decreased number of germinal center B cells and germinal center foci post immunization
• the germinal center area is greatly reduced
• total cellularity of Peyer's Patches is substantially reduced
• content of secreted IgA in the feces is dramatically reduced
• but serum IgA is normal
• reduced to levels close to the null mouse
• reduced to levels close to the null mouse
• reduced to levels close to the null mouse
• expression analysis of CD4 T-cells shows decreased IL-21 in response to secondary activation
• expression analysis of CD4 T-cells shows decreased IL-4 in response to secondary activation

hematopoietic system
• upon immunization
• drastic reduction in the percentage of germinal B cells relative to the total number of B cells
• percentage of TFH (CXCR5+, ICOS+) cells reduced by 5- to 9-fold in the Peyer's patch and spleen
• decreased number of germinal center B cells and germinal center foci post immunization
• content of secreted IgA in the feces is dramatically reduced
• but serum IgA is normal
• reduced to levels close to the null mouse
• reduced to levels close to the null mouse
• reduced to levels close to the null mouse





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory