immune system
• upon immunization
|
• drastic reduction in the percentage of germinal B cells relative to the total number of B cells
|
• percentage of TFH (CXCR5+, ICOS+) cells reduced by 5- to 9-fold in the Peyer's patch and spleen
|
• decreased number of germinal center B cells and germinal center foci post immunization
|
• the germinal center area is greatly reduced
|
• total cellularity of Peyer's Patches is substantially reduced
|
• upon immunization
|
• content of secreted IgA in the feces is dramatically reduced
• but serum IgA is normal
|
• reduced to levels close to the null mouse
|
• reduced to levels close to the null mouse
|
• reduced to levels close to the null mouse
|
• expression analysis of CD4 T-cells shows decreased IL-21 in response to secondary activation
|
• expression analysis of CD4 T-cells shows decreased IL-4 in response to secondary activation
|
hematopoietic system
• upon immunization
|
• drastic reduction in the percentage of germinal B cells relative to the total number of B cells
|
• percentage of TFH (CXCR5+, ICOS+) cells reduced by 5- to 9-fold in the Peyer's patch and spleen
|
• decreased number of germinal center B cells and germinal center foci post immunization
|
• upon immunization
|
• content of secreted IgA in the feces is dramatically reduced
• but serum IgA is normal
|
• reduced to levels close to the null mouse
|
• reduced to levels close to the null mouse
|
• reduced to levels close to the null mouse
|