Phenotypes associated with this allele

• Allele Symbol: Tlr9^m6Btlr
• Allele Name: mutation 6, Bruce Beutler
• Allele ID: MGI:4415350
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tlr9^m6Btlr/Tlr9^m6Btlr	C57BL/6J-Tlr9^m6Btlr	MGI:4415352

Genotype
MGI:4415352

hm1

• Allelic Composition: Tlr9^m6Btlr/Tlr9^m6Btlr
• Genetic Background: C57BL/6J-Tlr9^m6Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

increased susceptibility to induced colitis ( J:155728 )

• by the fourth day consuming drinking water containing 1% dextran sodium sulfate (DSS), homozygous mutant mice exhibit severe intestinal bleeding

• by the fourth day on 1% DSS, mice homozygous for this mutation exhibit greater weight loss than wild-type C57BL/6J controls; on day 5, they have lost 16% more weight than controls

• homozygous mutant mice die after 5 days' exposure to DSS

immune system

increased susceptibility to induced colitis ( J:155728 )

• by the fourth day consuming drinking water containing 1% dextran sodium sulfate (DSS), homozygous mutant mice exhibit severe intestinal bleeding

• by the fourth day on 1% DSS, mice homozygous for this mutation exhibit greater weight loss than wild-type C57BL/6J controls; on day 5, they have lost 16% more weight than controls

• homozygous mutant mice die after 5 days' exposure to DSS