All Phenotypes Chst1<tm1(KOMP)Vlcg> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Chst1^{tm1(KOMP)Vlcg}
targeted mutation 1, Velocigene
MGI:4415360

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chst1^{tm1(KOMP)Vlcg}/Chst1^{tm1(KOMP)Vlcg}	involves: C57BL/6NTac	MGI:5543505
cx2	Chst1^{tm1(KOMP)Vlcg}/Chst1^{tm1(KOMP)Vlcg} Chst2^tm1Tmu/Chst2^tm1Tmu Chst4^tm1Sdr/Chst4^tm1Sdr	involves: 129S2/SvPas * C57BL/6NTac	MGI:5543506

Allelic Composition	Chst1^{tm1(KOMP)Vlcg}/Chst1^{tm1(KOMP)Vlcg}
Genetic Background	involves: C57BL/6NTac
Cell Lines	10172A-D6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst1^{tm1(KOMP)Vlcg} mutation (2 available); any Chst1 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:204813 )

N	• mice are born in Mendelian ratios

immune system

immune system phenotype ( J:204813 )

N	• lymphocyte homing is normal

decreased B cell number ( J:204813 )

• small decreased in the peripheral and mesenteric lymph nodes and peripheral blood

increased T cell number ( J:204813 )

• small increase in the peripheral lymph nodes and peripheral blood

behavior/neurological

increased aggression towards mice ( J:204813 )

• male siblings housed together seem particularly prone to fighting

hematopoietic system

decreased B cell number ( J:204813 )

• small decreased in the peripheral and mesenteric lymph nodes and peripheral blood

increased T cell number ( J:204813 )

• small increase in the peripheral lymph nodes and peripheral blood

Allelic Composition	Chst1^{tm1(KOMP)Vlcg}/Chst1^{tm1(KOMP)Vlcg} Chst2^tm1Tmu/Chst2^tm1Tmu Chst4^tm1Sdr/Chst4^tm1Sdr
Genetic Background	involves: 129S2/SvPas * C57BL/6NTac
Cell Lines	10172A-D6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst1^{tm1(KOMP)Vlcg} mutation (2 available); any Chst1 mutation (20 available)
Chst2^tm1Tmu mutation (1 available); any Chst2 mutation (21 available)
Chst4^tm1Sdr mutation (1 available); any Chst4 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal leukocyte migration ( J:204813 )

• mice exhibit increased L-selectin-dependent homing to the peripheral lymph nodes compared with control mice

• however, homing to mesenteric lymph nodes is normal

cellular

abnormal leukocyte migration ( J:204813 )

• mice exhibit increased L-selectin-dependent homing to the peripheral lymph nodes compared with control mice

• however, homing to mesenteric lymph nodes is normal

hematopoietic system

abnormal leukocyte migration ( J:204813 )

• mice exhibit increased L-selectin-dependent homing to the peripheral lymph nodes compared with control mice

• however, homing to mesenteric lymph nodes is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24