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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chst1tm1(KOMP)Vlcg
targeted mutation 1, Velocigene
MGI:4415360
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Chst1tm1(KOMP)Vlcg/Chst1tm1(KOMP)Vlcg involves: C57BL/6NTac MGI:5543505
cx2
 		Chst1tm1(KOMP)Vlcg/Chst1tm1(KOMP)Vlcg
Chst2tm1Tmu/Chst2tm1Tmu
Chst4tm1Sdr/Chst4tm1Sdr 		involves: 129S2/SvPas * C57BL/6NTac MGI:5543506


Genotype
MGI:5543505
hm1
Allelic
Composition		 Chst1tm1(KOMP)Vlcg/Chst1tm1(KOMP)Vlcg
Genetic
Background		 involves: C57BL/6NTac
Cell Lines 10172A-D6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst1tm1(KOMP)Vlcg mutation (2 available); any Chst1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:204813 )
N
• mice are born in Mendelian ratios

immune system
immune system phenotype ( J:204813 )
N
• lymphocyte homing is normal
decreased B cell number ( J:204813 )
• small decreased in the peripheral and mesenteric lymph nodes and peripheral blood
increased T cell number ( J:204813 )
• small increase in the peripheral lymph nodes and peripheral blood

behavior/neurological
increased aggression towards mice ( J:204813 )
• male siblings housed together seem particularly prone to fighting

hematopoietic system
decreased B cell number ( J:204813 )
• small decreased in the peripheral and mesenteric lymph nodes and peripheral blood
increased T cell number ( J:204813 )
• small increase in the peripheral lymph nodes and peripheral blood




Genotype
MGI:5543506
cx2
Allelic
Composition		 Chst1tm1(KOMP)Vlcg/Chst1tm1(KOMP)Vlcg
Chst2tm1Tmu/Chst2tm1Tmu
Chst4tm1Sdr/Chst4tm1Sdr
Genetic
Background		 involves: 129S2/SvPas * C57BL/6NTac
Cell Lines 10172A-D6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst1tm1(KOMP)Vlcg mutation (2 available); any Chst1 mutation (20 available)
Chst2tm1Tmu mutation (1 available); any Chst2 mutation (21 available)
Chst4tm1Sdr mutation (1 available); any Chst4 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte migration ( J:204813 )
• mice exhibit increased L-selectin-dependent homing to the peripheral lymph nodes compared with control mice
• however, homing to mesenteric lymph nodes is normal

cellular
abnormal leukocyte migration ( J:204813 )
• mice exhibit increased L-selectin-dependent homing to the peripheral lymph nodes compared with control mice
• however, homing to mesenteric lymph nodes is normal

hematopoietic system
abnormal leukocyte migration ( J:204813 )
• mice exhibit increased L-selectin-dependent homing to the peripheral lymph nodes compared with control mice
• however, homing to mesenteric lymph nodes is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory