Phenotypes associated with this allele

• Allele Symbol: Lyg1^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:4415415
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lyg1^tm1(KOMP)Vlcg/Lyg1^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:6357195

Genotype
MGI:6357195

hm1

• Allelic Composition: Lyg1^{tm1(KOMP)Vlcg}/Lyg1^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor growth/size ( J:256594 )

• accelerated tumor growth in a B16 melanoma and a LLC-1 graft model

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:256594 )

decreased CD8-positive, alpha-beta T cell number ( J:256594 )

immune system

decreased CD4-positive, alpha-beta T cell number ( J:256594 )

decreased CD8-positive, alpha-beta T cell number ( J:256594 )

decreased interferon-gamma secretion ( J:256594 )

• decreased production/secretion by T cells