Phenotypes associated with this allele

• Allele Symbol: Lst1^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:4415420
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lst1^tm1(KOMP)Vlcg/Lst1^tm1(KOMP)Vlcg	C57BL/6N-Lst1^tm1(KOMP)Vlcg	MGI:5806920

Genotype
MGI:5806920

hm1

• Allelic Composition: Lst1^{tm1(KOMP)Vlcg}/Lst1^{tm1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Lst1^{tm1(KOMP)Vlcg}
• Cell Lines: 12118A-B1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:235700 )

♂N • following intranasal infection with an H3N2 influenza A virus (A/HK/01/68; 2x10³ FFU), male homozygotes show no significant differences in body weight loss or survival rate relative to similarly infected C57BL/6J males

increased susceptibility to Orthomyxoviridae infection ( J:235700 )

♀ • following intranasal infection with a low-virulent H1N1 influenza A virus (PR8M; 210⁵ FFU), female homozygotes show a significantly greater body weight loss at days 5 and 6 p.i. than wild-type controls

♀ • however, viral loads, histopathology, and immune cell composition in bronchoalveolar lavage of PR8M-infected lungs are not significantly altered at days 3 and 5 p.i. relative to wild-type controls

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:235700 )

♀ • following intranasal infection with 210⁵ FFU PR8M, female homozygotes show a slight increase in lethality (20%) between days 6 and 7 p.i., whereas all PR8M-infected wild-type mice survive to 14 p.i.

mortality/aging

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:235700 )

♀ • following intranasal infection with 210⁵ FFU PR8M, female homozygotes show a slight increase in lethality (20%) between days 6 and 7 p.i., whereas all PR8M-infected wild-type mice survive to 14 p.i.