Phenotypes associated with this allele

• Allele Symbol: Tle2^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:4415479
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tle2^tm1(KOMP)Vlcg/Tle2^tm1(KOMP)Vlcg	C57BL/6-Tle2^tm1(KOMP)Vlcg	MGI:7859476
cn2	Tle2^tm1(KOMP)Vlcg/Tle2^tm1(KOMP)Vlcg Tle3^tm1.1Pton/Tle3^tm1.1Pton Tg(Pdx1-cre)6Tuv/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:7859479

Genotype
MGI:7859476

hm1

• Allelic Composition: Tle2^{tm1(KOMP)Vlcg}/Tle2^{tm1(KOMP)Vlcg}
• Genetic Background: C57BL/6-Tle2^{tm1(KOMP)Vlcg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:307817 )

• mice live into adulthood with no apparent defects; they are euglycemic at 4 weeks and do not exhibit any overt pancreatic islet phenotypes at 6 weeks of age

Genotype
MGI:7859479

cn2

• Allelic Composition: Tle2^{tm1(KOMP)Vlcg}/Tle2^{tm1(KOMP)Vlcg}; Tle3^tm1.1Pton/Tle3^tm1.1Pton; Tg(Pdx1-cre)6Tuv/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

homeostasis/metabolism

impaired glucose tolerance ( J:307817 )

• double knockout mice are glucose intolerant at 8 weeks of age, with no significant worsening of the Tle3 (Grg3) single knockout phenotype

endocrine/exocrine glands

decreased pancreatic beta cell number ( J:307817 )

• pancreatic islets isolated from 7-mo-old double knockout mice show an obvious decrease in the number of INS+ beta cells that is similar to that in Tle3 (Grg3) single knockout mice