Phenotypes associated with this allele

• Allele Symbol: Dnai1^tm1.1Leo
• Allele Name: targeted mutation 1.1, Lawrence E Ostrowski
• Allele ID: MGI:4415595
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnai1^tm1.1Leo/Dnai1^tm1.1Leo	Not Specified	MGI:4461789
cn2	Dnai1^tm1.1Leo/Dnai1^tm1.1Leo Gt(ROSA)26Sor^tm1(cre/ERT)Nat/Gt(ROSA)26Sor^+	involves: 129 * C57BL/6	MGI:4415702

Genotype
MGI:4461789

hm1

• Allelic Composition: Dnai1^tm1.1Leo/Dnai1^tm1.1Leo
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal respiratory sounds ( J:161297 )

• mice exhibit coughing or sneezing-like noises unlike wild-type mice

coughing ( J:161297 )

• mice exhibit coughing-like noises

sneezing ( J:161297 )

• mice exhibit sneezing-like noises

Genotype
MGI:4415702

cn2

• Allelic Composition: Dnai1^tm1.1Leo/Dnai1^tm1.1Leo; Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129 * C57BL/6

respiratory system

abnormal respiratory system physiology ( J:155730 )

• following treatment with tamoxifen, cultured tracheal ciliated epithelium exhibits no ciliary activity likely due to a lack of outer dynein arms unlike similarly treated wild-type samples

• however, epithelium morphology and number of ciliated cells are normal following treatment with tamoxifen

rhinosinusitis ( J:155730 )

• tamoxifen-treated mice exhibit chronic rhinosinusitis unlike wild-type mice

• however, no lung inflammation develops in tamoxifen-treated mice

abnormal mucociliary clearance ( J:155730 )

• after 3 months, tamoxifen-treated mice exhibit absent mucociliary clearance in the nasopharynx and a 50% decreased in the trachea compared with wild-type mice

• after 6 months, 3 of 4 tamoxifen-treated mice exhibit no mucociliary clearance in the trachea while 1 of 4 mice exhibit a substantial reduction in clearance compared with similarly treated wild-type mice

• after 7.5 months, tamoxifen-treated mice exhibit no mucociliary clearance in the trachea compared with similarly treated wild-type mice

immune system

rhinosinusitis ( J:155730 )

• tamoxifen-treated mice exhibit chronic rhinosinusitis unlike wild-type mice

• however, no lung inflammation develops in tamoxifen-treated mice

nervous system

nervous system phenotype ( J:155730 )

N • despite ciliary defects, tamoxifen-treated mice exhibit no evidence hydroencephaly

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary ciliary dyskinesia 1		DOID:0110594	OMIM:244400	J:155730