Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
NOT | cerebral amyloid angiopathy | DOID:9246 | J:155411 |
Allele Symbol Allele Name Allele ID |
Itm2btm2.1Ldad targeted mutation 2.1, Luciano D'Adamio MGI:4415610 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
Signs of melanosis in the meninges of the olfactory bulb and mineralization in the thalamus of Itm2btm2.1Ldad/Itm2btm2.1Ldad mice
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
NOT | cerebral amyloid angiopathy | DOID:9246 | J:155411 |
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• at 5 to 6 months and 7 to 8 months, mice spend equal time exploring novel and old objects unlike wild-type mice
• at 11 months, mice exhibit profound memory impairment compared with wild-type mice
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• at 5 to 6 months, 7 to 8 months, and 11 months, mice exhibit impaired spatial working memory in a radial-arm water maze compared with wild-type mice
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N |
• mice do not exhibit neuron loss or taupathy
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• at 11 to 13 months
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
cerebral amyloid angiopathy | DOID:9246 | J:167154 |
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice exhibit normal spatial working memory and novel object recognition
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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