Phenotypes associated with this allele

• Allele Symbol: Itm2b^tm2.1Ldad
• Allele Name: targeted mutation 2.1, Luciano D'Adamio
• Allele ID: MGI:4415610
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itm2b^tm2.1Ldad/Itm2b^tm2.1Ldad	B6.129-Itm2b^tm2.1Ldad	MGI:4415612
ht2	Itm2b^tm2.1Ldad/Itm2b^+	B6.129-Itm2b^tm2.1Ldad	MGI:4936849
cx3	Itm2b^tm2.1Ldad/Itm2b^+ Tg(Camk2a-ITM2B)8.4Ldad/0	B6.Cg-Itm2b^tm2.1Ldad Tg(Camk2a-ITM2B)8.4Ldad	MGI:4936848

Genotype
MGI:4415612

hm1

• Allelic Composition: Itm2b^tm2.1Ldad/Itm2b^tm2.1Ldad
• Genetic Background: B6.129-Itm2b^tm2.1Ldad

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Signs of melanosis in the meninges of the olfactory bulb and mineralization in the thalamus of Itm2b^tm2.1Ldad/Itm2b^tm2.1Ldad mice

nervous system

nervous system phenotype ( J:155411 )

N • absence of expected amyloid lesion

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	cerebral amyloid angiopathy	DOID:9246		J:155411

Genotype
MGI:4936849

ht2

• Allelic Composition: Itm2b^tm2.1Ldad/Itm2b⁺
• Genetic Background: B6.129-Itm2b^tm2.1Ldad

behavior/neurological

impaired contextual conditioning behavior ( J:167154 )

abnormal object recognition memory ( J:167154 )

• at 5 to 6 months and 7 to 8 months, mice spend equal time exploring novel and old objects unlike wild-type mice

• at 11 months, mice exhibit profound memory impairment compared with wild-type mice

impaired spatial working memory ( J:167154 )

• at 5 to 6 months, 7 to 8 months, and 11 months, mice exhibit impaired spatial working memory in a radial-arm water maze compared with wild-type mice

nervous system

nervous system phenotype ( J:167154 )

N • mice do not exhibit neuron loss or taupathy

reduced long-term potentiation ( J:167154 )

• at 11 to 13 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cerebral amyloid angiopathy		DOID:9246		J:167154

Genotype
MGI:4936848

cx3

• Allelic Composition: Itm2b^tm2.1Ldad/Itm2b⁺; Tg(Camk2a-ITM2B)8.4Ldad/0
• Genetic Background: B6.Cg-Itm2b^tm2.1Ldad Tg(Camk2a-ITM2B)8.4Ldad

behavior/neurological

behavior/neurological phenotype ( J:167154 )

N • mice exhibit normal spatial working memory and novel object recognition