Phenotypes associated with this allele

• Allele Symbol: Tbx2^{tm1.1(cre)Vmc}
• Allele Name: targeted mutation 1.1, Vincent M Christoffels
• Allele ID: MGI:4415614
• Summary: 8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbx2^tm1.1(cre)Vmc/Tbx2^tm1.1(cre)Vmc	involves: 129P2/OlaHsd * FVB	MGI:4418058
hm2	Tbx2^tm1.1(cre)Vmc/Tbx2^tm1.1(cre)Vmc	involves: 129P2/OlaHsd * NMRI	MGI:4418054
ht3	Tbx2^tm1.1(cre)Vmc/Tbx2^+	involves: 129P2/OlaHsd * NMRI	MGI:4418056
cx4	Tbx2^tm1.1(cre)Vmc/Tbx2^tm1.1(cre)Vmc Tbx3^tm1.1(cre)Vmc/Tbx3^tm1.1(cre)Vmc	involves: 129P2/OlaHsd	MGI:5314603
cx5	Tbx2^tm1.1(cre)Vmc/Tbx2^tm1.1(cre)Vmc Tbx3^tm1.1(cre)Vmc/Tbx3^tm1.1(cre)Vmc	involves: 129P2/OlaHsd * FVB/N	MGI:4418050
cx6	Tbx2^tm1.1(cre)Vmc/Tbx2^tm1.1(cre)Vmc Tbx3^tm1.1(cre)Vmc/Tbx3^+	involves: 129P2/OlaHsd * FVB/N * NMRI	MGI:4418052
cx7	Tbx2^tm1.1(cre)Vmc/Tbx2^+ Tbx3^tm1.1(cre)Vmc/Tbx3^tm1.1(cre)Vmc	involves: 129P2/OlaHsd * FVB/N * NMRI	MGI:4418051
cx8	Tbx2^tm1.1(cre)Vmc/Tbx2^+ Tbx3^tm1.1(cre)Vmc/Tbx3^+	involves: 129P2/OlaHsd * FVB/N * NMRI	MGI:4418053

Genotype
MGI:4418058

hm1

• Allelic Composition: Tbx2^{tm1.1(cre)Vmc}/Tbx2^{tm1.1(cre)Vmc}
• Genetic Background: involves: 129P2/OlaHsd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

polydactyly ( J:154920 )

• bilateral hindlimb-specific duplication of digit IV is observed

Genotype
MGI:4418054

hm2

• Allelic Composition: Tbx2^{tm1.1(cre)Vmc}/Tbx2^{tm1.1(cre)Vmc}
• Genetic Background: involves: 129P2/OlaHsd * NMRI

craniofacial

abnormal palatal mesenchymal cell proliferation ( J:154920 )

• mesenchymal cell proliferation is significantly increased at E12.5 in the anterior region, but not in the posterior region at this age, or in either region at E14.0

decreased palatal shelf size ( J:154920 )

• at E13.5, palatal shelves appear smaller and have moved less down the tongue compared to wild type

• at E14.0, a significant reduction in size of the anterior region of the palatal shelves is detected with no significant changes in cell densities in the anterior or posterior aspects

cleft secondary palate ( J:154920 )

• at E18.5 and 15.5, 18 of 21 embryos analyzed show a complete cleft of the secondary palate

delayed palatal shelf elevation ( J:154920 )

• morphogenesis of the palatal shelves is severely retarded and comes to a premature hold with elevated palatal shelves only apparent at E14.5 in contrast to wild-type where elevated shelves are seen at E14.25 and fusion occurs between E14.5 and 15.5

limbs/digits/tail

polydactyly ( J:154920 )

• bilateral hindlimb-specific duplication of digit IV is observed

digestive/alimentary system

abnormal palatal mesenchymal cell proliferation ( J:154920 )

• mesenchymal cell proliferation is significantly increased at E12.5 in the anterior region, but not in the posterior region at this age, or in either region at E14.0

decreased palatal shelf size ( J:154920 )

• at E13.5, palatal shelves appear smaller and have moved less down the tongue compared to wild type

• at E14.0, a significant reduction in size of the anterior region of the palatal shelves is detected with no significant changes in cell densities in the anterior or posterior aspects

cleft secondary palate ( J:154920 )

• at E18.5 and 15.5, 18 of 21 embryos analyzed show a complete cleft of the secondary palate

delayed palatal shelf elevation ( J:154920 )

• morphogenesis of the palatal shelves is severely retarded and comes to a premature hold with elevated palatal shelves only apparent at E14.5 in contrast to wild-type where elevated shelves are seen at E14.25 and fusion occurs between E14.5 and 15.5

growth/size/body

abnormal palatal mesenchymal cell proliferation ( J:154920 )

• mesenchymal cell proliferation is significantly increased at E12.5 in the anterior region, but not in the posterior region at this age, or in either region at E14.0

decreased palatal shelf size ( J:154920 )

• at E13.5, palatal shelves appear smaller and have moved less down the tongue compared to wild type

• at E14.0, a significant reduction in size of the anterior region of the palatal shelves is detected with no significant changes in cell densities in the anterior or posterior aspects

cleft secondary palate ( J:154920 )

• at E18.5 and 15.5, 18 of 21 embryos analyzed show a complete cleft of the secondary palate

delayed palatal shelf elevation ( J:154920 )

• morphogenesis of the palatal shelves is severely retarded and comes to a premature hold with elevated palatal shelves only apparent at E14.5 in contrast to wild-type where elevated shelves are seen at E14.25 and fusion occurs between E14.5 and 15.5

Genotype
MGI:4418056

ht3

• Allelic Composition: Tbx2^{tm1.1(cre)Vmc}/Tbx2⁺
• Genetic Background: involves: 129P2/OlaHsd * NMRI

normal phenotype

no abnormal phenotype detected ( J:154920 )

• mice are phenotypically normal on this outbred background

Genotype
MGI:5314603

cx4

• Allelic Composition: Tbx2^{tm1.1(cre)Vmc}/Tbx2^{tm1.1(cre)Vmc}; Tbx3^{tm1.1(cre)Vmc}/Tbx3^{tm1.1(cre)Vmc}
• Genetic Background: involves: 129P2/OlaHsd

cardiovascular system

abnormal heart development ( J:181526 )

• mice exhibit abrogation of myocardial patterning of the atrioventricular canal and largely lack the constriction between the left ventricle and atrium

abnormal cardiac jelly morphology ( J:181526 )

• partial loss

absent atrioventricular cushions ( J:181526 )

embryo

embryonic growth retardation ( J:181526 )

• slightly retarded at E9.5

growth/size/body

embryonic growth retardation ( J:181526 )

• slightly retarded at E9.5

Genotype
MGI:4418050

cx5

• Allelic Composition: Tbx2^{tm1.1(cre)Vmc}/Tbx2^{tm1.1(cre)Vmc}; Tbx3^{tm1.1(cre)Vmc}/Tbx3^{tm1.1(cre)Vmc}
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

craniofacial

cleft secondary palate ( J:154920 )

• 11 of 13 embryos show complete cleft palate

digestive/alimentary system

cleft secondary palate ( J:154920 )

• 11 of 13 embryos show complete cleft palate

growth/size/body

cleft secondary palate ( J:154920 )

• 11 of 13 embryos show complete cleft palate

Genotype
MGI:4418052

cx6

• Allelic Composition: Tbx2^{tm1.1(cre)Vmc}/Tbx2^{tm1.1(cre)Vmc}; Tbx3^{tm1.1(cre)Vmc}/Tbx3⁺
• Genetic Background: involves: 129P2/OlaHsd * FVB/N * NMRI

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:154920 )

• the limited number of embryos obtained from intercrosses die at E10.5 due to hemodynamic failure

Genotype
MGI:4418051

cx7

• Allelic Composition: Tbx2^{tm1.1(cre)Vmc}/Tbx2⁺; Tbx3^{tm1.1(cre)Vmc}/Tbx3^{tm1.1(cre)Vmc}
• Genetic Background: involves: 129P2/OlaHsd * FVB/N * NMRI

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:154920 )

• the limited number of embryos obtained from intercrosses die at E10.5 due to hemodynamic failure

Genotype
MGI:4418053

cx8

• Allelic Composition: Tbx2^{tm1.1(cre)Vmc}/Tbx2⁺; Tbx3^{tm1.1(cre)Vmc}/Tbx3⁺
• Genetic Background: involves: 129P2/OlaHsd * FVB/N * NMRI

craniofacial

cleft secondary palate ( J:154920 )

• 5 of 13 embryos show complete cleft palate at E18.5

digestive/alimentary system

cleft secondary palate ( J:154920 )

• 5 of 13 embryos show complete cleft palate at E18.5

growth/size/body

cleft secondary palate ( J:154920 )

• 5 of 13 embryos show complete cleft palate at E18.5