Analysis Tools
mortality/aging
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• 80% of mice die within the first 48 hours after birth
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nervous system
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• 29% lower than in wild-type mice at P90
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• at P90
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• at P90, the neuronal cell density in the cortex is greater than in wild-type mice
• at P90, mice exhibit cortical shrinkage compared with wild-type mice
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• at P90
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• mice exhibit impaired axonal maturation in the central and peripheral nervous system compared with wild-type mice
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• at P30 and P365, the thickness of myelin sheaths is reduced compared to in wild-type mice
• however, differentiation of oligodendrocytes is normal
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• at P30 and P365, the nerves in the Remak bundles of the sciatic nerve is two-fold more than in wild-type mice
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• mice exhibit hypomyelination of axons in the cortex, hippocampus, and corpus callosum compared with wild-type mice
• mice exhibit delayed initiation of myelination and hypomyelination in the central and peripheral nervous system
• at P14, only one seventh of axons are myelinated unlike in wild-type mice
• at P90, only 21% of axons are myelinated unlike in wild-type mice
• however, differentiation of oligodendrocytes is normal
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behavior/neurological
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• mice exhibit reduced correct choices in a forced-alternation task compared with wild-type mice
• however, reference memory is normal
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• in a beam test, mice move slower and slip more frequently than wild-type mice
• mice exhibit reduced latency to fall on a rotarod compared with wild-type mice
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• mice exhibit reduced grip strength compared with wild-type mice
• however, mice exhibit normal behavior in a wire-hanging test
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growth/size/body
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• 30% less than wild-type mice
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• surviving mice remain smaller than wild-type mice
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