All Phenotypes Tnfrsf11a<tm1.1Pngr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tnfrsf11a^tm1.1Pngr
targeted mutation 1.1, Josef M Penninger
MGI:4415800

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tnfrsf11a^tm1.1Pngr/Tnfrsf11a^tm1.2Pngr Tg(Gfap-cre)2Brn/0	involves: 129 * C57BL/6 * C57BL/6NTac * FVB/N	MGI:4415817
cn2	Tnfrsf11a^tm1.1Pngr/Tnfrsf11a^tm1.2Pngr Tg(Nes-cre)1Kln/0	involves: 129 * C57BL/6 * C57BL/6NTac * SJL	MGI:4415816
cn3	Tg(Bglap2-TAg)1Rkho/0 Tg(Col1a1-cre)1Kry/0 Tnfrsf11a^tm1.1Pngr/Tnfrsf11a^tm1.1Pngr	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5796173

Allelic Composition	Tnfrsf11a^tm1.1Pngr/Tnfrsf11a^tm1.2Pngr Tg(Gfap-cre)2Brn/0
Genetic Background	involves: 129 * C57BL/6 * C57BL/6NTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gfap-cre)2Brn mutation (1 available)
Tnfrsf11a^tm1.1Pngr mutation (0 available); any Tnfrsf11a mutation (42 available)
Tnfrsf11a^tm1.2Pngr mutation (0 available); any Tnfrsf11a mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal body temperature homeostasis ( J:155398 )

• ovariectomized mice fail to exhibit a change in body temperature unlike similarly treated wild-type mice

abnormal circadian temperature homeostasis ( J:155398 )

• in female mice during the light phase

impaired febrile response ( J:155398 )

• mice injected with RANKL (Tnfsf11) or LPS fail to develop severe hyperthermia unlike similarly treated wild-type mice

decreased prostaglandin level ( J:155398 )

• mice injected with RANKL (Tnfsf11) fail to exhibit an increase in prostagladin levels unlike similarly treated wild-type mice

abnormal response/metabolism to endogenous compounds ( J:155398 )

• mice injected with RANKL (Tnfsf11) fail to develop severe hyperthermia and do not exhibit a change in diurnal activity unlike similarly treated wild-type mice

• mice injected with Il1b or TNF exhibit an impaired fever response and alterations in circadian activity compared with similarly treated wild-type mice

• mice injected with RANKL (Tnfsf11) fail to exhibit an increase in prostagladin levels unlike similarly treated wild-type mice

immune system

decreased susceptibility to endotoxin shock ( J:155398 )

• mice injected with LPS fail to develop severe hyperthermia and do not exhibit a change in diurnal activity unlike similarly treated wild-type mice

Allelic Composition	Tnfrsf11a^tm1.1Pngr/Tnfrsf11a^tm1.2Pngr Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129 * C57BL/6 * C57BL/6NTac * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Tnfrsf11a^tm1.1Pngr mutation (0 available); any Tnfrsf11a mutation (42 available)
Tnfrsf11a^tm1.2Pngr mutation (0 available); any Tnfrsf11a mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal body temperature homeostasis ( J:155398 )

• ovariectomized mice fail to exhibit a change in body temperature unlike similarly treated wild-type mice

abnormal circadian temperature homeostasis ( J:155398 )

• in female mice during the light phase

impaired febrile response ( J:155398 )

• mice injected with RANKL (Tnfsf11) or LPS fail to develop severe hyperthermia unlike similarly treated wild-type mice

decreased prostaglandin level ( J:155398 )

• mice injected with RANKL (Tnfsf11) fail to exhibit an increase in prostagladin levels unlike similarly treated wild-type mice

abnormal response/metabolism to endogenous compounds ( J:155398 )

• mice injected with RANKL (Tnfsf11) fail to develop severe hyperthermia and do not exhibit a change in diurnal activity unlike similarly treated wild-type mice

• mice injected with Il1b or TNF exhibit an impaired fever response and alterations in circadian activity compared with similarly treated wild-type mice

• mice injected with RANKL (Tnfsf11) fail to exhibit an increase in prostagladin levels unlike similarly treated wild-type mice

immune system

decreased susceptibility to endotoxin shock ( J:155398 )

• mice injected with LPS fail to develop severe hyperthermia and do not exhibit a change in diurnal activity unlike similarly treated wild-type mice

Allelic Composition	Tg(Bglap2-TAg)1Rkho/0 Tg(Col1a1-cre)1Kry/0 Tnfrsf11a^tm1.1Pngr/Tnfrsf11a^tm1.1Pngr
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Bglap2-TAg)1Rkho mutation (0 available)
Tg(Col1a1-cre)1Kry mutation (2 available)
Tnfrsf11a^tm1.1Pngr mutation (0 available); any Tnfrsf11a mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased osteosarcoma incidence ( J:234128 )

• tumor onset, survival, tumor burden, and lung metastasis is comparable to single Tg(Bglap2-TAg)1Rkho hemizygous mice

skeleton

increased osteosarcoma incidence ( J:234128 )

• tumor onset, survival, tumor burden, and lung metastasis is comparable to single Tg(Bglap2-TAg)1Rkho hemizygous mice

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