About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atg9atm1Aki
targeted mutation 1, Shizuo Akira
MGI:4417824
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atg9atm1Aki/Atg9atm1Aki involves: 129/Sv * C57BL/6 MGI:4417825


Genotype
MGI:4417825
hm1
Allelic
Composition
Atg9atm1Aki/Atg9atm1Aki
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg9atm1Aki mutation (0 available); any Atg9a mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• MEFs fail to produce autophagasomes after growth under nutrient-starvation
• MEFs fail to produce autophagasomes after growth under nutrient-starvation
• decrease in the bulk degradation of long-lived proteins

mortality/aging
• all die within 1 day of birth

cellular
• MEFs fail to produce autophagasomes after growth under nutrient-starvation
• MEFs fail to produce autophagasomes after growth under nutrient-starvation
• decrease in the bulk degradation of long-lived proteins

immune system
• expression and protein production of IFN-beta are increased in dsDNA stimulated MEFs
• expression of interleukin-6 is increased in dsDNA stimulated MEFs
• abnormal response of MEFs to dsDNA stimulation





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory