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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il15ratm2.1Ama
targeted mutation 2.1, Averil Ma
MGI:4417841
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Il15ratm1Ama/Il15ratm2.1Ama
Lyz2tm1(cre)Ifo/0
Tg(Itgax-cre)1-1Reiz/0 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA MGI:4417844
cn2
 		Il15ratm1Ama/Il15ratm2.1Ama
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J MGI:4417843
cn3
 		Il15ratm1Ama/Il15ratm2.1Ama
Tg(Itgax-cre)1-1Reiz/0 		involves: 129X1/SvJ * C57BL/6J * CBA MGI:4417842
cn4
 		Il15ratm1Ama/Il15ratm2.1Ama
Tg(Vil1-cre)997Gum/0 		involves: C57BL/6J * SJL MGI:4417845


Genotype
MGI:4417844
cn1
Allelic
Composition		 Il15ratm1Ama/Il15ratm2.1Ama
Lyz2tm1(cre)Ifo/0
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15ratm1Ama mutation (1 available); any Il15ra mutation (39 available)
Il15ratm2.1Ama mutation (1 available); any Il15ra mutation (39 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK cell number ( J:155298 )
• about half the number of NK cells in the spleen, lymph node, liver, and lung
• but no decrease is seen in the bone marrow
decreased CD8-positive, alpha-beta T cell number ( J:155298 )
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
decreased memory T cell number ( J:155298 )
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
abnormal immune system physiology ( J:155298 )
• decrease in the numbers of adoptively transferred transgenic CD8+ T cells compared to controls by 30 days after immunization

hematopoietic system
decreased NK cell number ( J:155298 )
• about half the number of NK cells in the spleen, lymph node, liver, and lung
• but no decrease is seen in the bone marrow
decreased CD8-positive, alpha-beta T cell number ( J:155298 )
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
decreased memory T cell number ( J:155298 )
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood




Genotype
MGI:4417843
cn2
Allelic
Composition		 Il15ratm1Ama/Il15ratm2.1Ama
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15ratm1Ama mutation (1 available); any Il15ra mutation (39 available)
Il15ratm2.1Ama mutation (1 available); any Il15ra mutation (39 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal NK cell differentiation ( J:155298 )
• increase in immature CD11b+ CXCR3+ NK cells in spleen and bone marrow
• more mature KLRG-1+ CD11b+ NK cells are underrepresented in spleen and bone marrow
decreased NK cell number ( J:155298 )
• about half the number of NK cells in the spleen, lymph node, liver, and lung
• but no decrease is seen in the bone marrow
decreased CD8-positive, alpha-beta T cell number ( J:155298 )
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
decreased memory T cell number ( J:155298 )
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
abnormal NK cell physiology ( J:155298 )
• decrease in proliferation of CD27+ CD11b+ cells
• decrease in activation of adoptively transferred wild-type NK cells in response to lipopolysaccaride

immune system
abnormal NK cell differentiation ( J:155298 )
• increase in immature CD11b+ CXCR3+ NK cells in spleen and bone marrow
• more mature KLRG-1+ CD11b+ NK cells are underrepresented in spleen and bone marrow
decreased NK cell number ( J:155298 )
• about half the number of NK cells in the spleen, lymph node, liver, and lung
• but no decrease is seen in the bone marrow
decreased CD8-positive, alpha-beta T cell number ( J:155298 )
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
decreased memory T cell number ( J:155298 )
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
abnormal immune system physiology ( J:155298 )
• exaggerated contraction of adoptively transferred transgenic CD8+ T cells seen as early as 10 days after immunization
abnormal NK cell physiology ( J:155298 )
• decrease in proliferation of CD27+ CD11b+ cells
• decrease in activation of adoptively transferred wild-type NK cells in response to lipopolysaccaride




Genotype
MGI:4417842
cn3
Allelic
Composition		 Il15ratm1Ama/Il15ratm2.1Ama
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15ratm1Ama mutation (1 available); any Il15ra mutation (39 available)
Il15ratm2.1Ama mutation (1 available); any Il15ra mutation (39 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal NK cell differentiation ( J:155298 )
• increase in immature CD11b+ CXCR3+ NK cells in spleen and bone marrow
• more mature KLRG-1+ CD11b+ NK cells are underrepresented in spleen and bone marrow
decreased NK cell number ( J:155298 )
• about half the number of NK cells in the spleen, lymph node, liver, and lung
• but no decrease is seen in the bone marrow
abnormal T cell subpopulation ratio ( J:155298 )
• marked decrease in the ratio of CD62Lhi to CD62Llo memory phenotype CD8+ T cells
decreased CD8-positive, alpha-beta T cell number ( J:155298 )
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
• marked decrease in the number of CD62Lhi memory phenotype CD8+ T cells
decreased memory T cell number ( J:155298 )
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
• marked decrease in the number of CD62Lhi memory phenotype CD8+ T cells
abnormal NK cell physiology ( J:155298 )
• decrease in proliferation of CD27+ CD11b+ cells
• decrease in activation of adoptively transferred wild-type NK cells in response to lipopolysaccaride

immune system
abnormal NK cell differentiation ( J:155298 )
• increase in immature CD11b+ CXCR3+ NK cells in spleen and bone marrow
• more mature KLRG-1+ CD11b+ NK cells are underrepresented in spleen and bone marrow
decreased NK cell number ( J:155298 )
• about half the number of NK cells in the spleen, lymph node, liver, and lung
• but no decrease is seen in the bone marrow
abnormal T cell subpopulation ratio ( J:155298 )
• marked decrease in the ratio of CD62Lhi to CD62Llo memory phenotype CD8+ T cells
decreased CD8-positive, alpha-beta T cell number ( J:155298 )
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
• marked decrease in the number of CD62Lhi memory phenotype CD8+ T cells
decreased memory T cell number ( J:155298 )
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
• marked decrease in the number of CD62Lhi memory phenotype CD8+ T cells
abnormal NK cell physiology ( J:155298 )
• decrease in proliferation of CD27+ CD11b+ cells
• decrease in activation of adoptively transferred wild-type NK cells in response to lipopolysaccaride




Genotype
MGI:4417845
cn4
Allelic
Composition		 Il15ratm1Ama/Il15ratm2.1Ama
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15ratm1Ama mutation (1 available); any Il15ra mutation (39 available)
Il15ratm2.1Ama mutation (1 available); any Il15ra mutation (39 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory