Phenotypes associated with this allele

• Allele Symbol: Acsl1^tm1Rcol
• Allele Name: targeted mutation 1, Rosalind Coleman
• Allele ID: MGI:4417846
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Acsl1^tm1Rcol/Acsl1^tm1Rcol Tg(Fabp4-cre)1Rev/0	involves: 129P2/OlaHsd * C57BL/6	MGI:6103877
cn2	Acsl1^tm1Rcol/Acsl1^tm1Rcol Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129P2/OlaHsd * C57BL/6 * DBA	MGI:4417849

Genotype
MGI:6103877

cn1

• Allelic Composition: Acsl1^tm1Rcol/Acsl1^tm1Rcol; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased fatty acid oxidation ( J:162996 )

• in white adipose tissue

impaired adaptive thermogenesis ( J:162996 )

• in cold exposed mice due to decreased fatty acid oxidation

hypoglycemia ( J:162996 )

• during cold exposure

• after adrenergic stimuli with isoproterenol or CL-316243

• however, glucose levels are normal after fasting

decreased circulating glycerol level ( J:162996 )

• in response to CL-316243 due to reduced glycerol release by brown adipocytes

hyperlipidemia ( J:162996 )

• after adrenergic stimuli

increased fatty acids level ( J:162996 )

• in white adipose tissue when fed a low-fat diet with different fatty acid species

increased circulating free fatty acids level ( J:162996 )

• after cold exposure or CL-316243 treatment

• however, fasting does not abnormally increase fatty acid levels

increased triglyceride level ( J:162996 )

• with increased diacylglycerol level in white adipose tissue when fed a low-fat diet

increased circulating triglyceride level ( J:162996 )

• after cold exposure

decreased lipoprotein lipase activity ( J:162996 )

• when fed a low-fat diet

adipose tissue

increased body fat mass ( J:162996 )

• when fed a 10% fat diet

• however, mice fed a high-fat diet exhibit normal weight gain and adipocity

increased epididymal fat pad weight ( J:162996 )

• when fed a low-fat diet

• however, mice fed a high-fat diet exhibit lipid levels

increased gonadal fat pad weight ( J:162996 )

• when fed a 10% fat diet or chow

• however, adipocyte size is normal

growth/size/body

increased body fat mass ( J:162996 )

• when fed a 10% fat diet

• however, mice fed a high-fat diet exhibit normal weight gain and adipocity

cellular

decreased fatty acid oxidation ( J:162996 )

• in white adipose tissue

Genotype
MGI:4417849

cn2

• Allelic Composition: Acsl1^tm1Rcol/Acsl1^tm1Rcol; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

growth/size/body

growth/size/body region phenotype ( J:155714 )

N • normal body weight and organ weights

adipose tissue

adipose tissue phenotype ( J:155714 )

N • normal adiposity

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:155714 )

N • normal plasma levels of metabolites

N • normal golucose tolerance tests and insulin tolerance tests

abnormal lipid homeostasis ( J:155714 )

• liver acyl-CoA levels are 35% lower than controls on a normal diet and 25% lower than controls on a high fat diet