All Phenotypes Tg(Rho-cre)#Yzl MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Rho-cre)#Yzl
transgene insertion, Yun-Zheng Le
MGI:4417915

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cp^tm1Hrs/Cp^tm1Hrs Heph^tm1.1Jdun/Heph^tm1.1Jdun Tg(BEST1-cre)1Jdun/0 Tg(Rho-cre)#Yzl/0	involves: 129X1/SvJ * C57BL/6 * C57BL/6NTac	MGI:5490775
cn2	Cp^tm1Hrs/Cp^tm1Hrs Heph^tm1.1Jdun/Heph^tm1.1Jdun Tg(Rho-cre)#Yzl/0	involves: 129X1/SvJ * C57BL/6NTac	MGI:5490774
cn3	Heph^tm1.1Jdun/Heph^tm1.1Jdun Tg(Rho-cre)#Yzl/0	involves: C57BL/6NTac	MGI:5490773
cn4	Elovl4^tm3Kzh/Elovl4^tm3Kzh Tg(Rho-cre)#Yzl/?	Not Specified	MGI:5492070

Allelic Composition	Cp^tm1Hrs/Cp^tm1Hrs Heph^tm1.1Jdun/Heph^tm1.1Jdun Tg(BEST1-cre)1Jdun/0 Tg(Rho-cre)#Yzl/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cp^tm1Hrs mutation (1 available); any Cp mutation (76 available)
Heph^tm1.1Jdun mutation (0 available); any Heph mutation (11 available)
Tg(BEST1-cre)1Jdun mutation (1 available)
Tg(Rho-cre)#Yzl mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal iron level ( J:196540 )

• iron levels in retinal pigment epithelium cells are not increased beyond levels in Cp^tm1Hrs/Cp^tm1Hrs Heph^tm1.1Itl/ Heph^tm1.1Itl Tg(BEST1-cre)1Jdun mice

abnormal protein level ( J:196540 )

• bipolar cells exhibit an increase in L-ferritin levels

Allelic Composition	Cp^tm1Hrs/Cp^tm1Hrs Heph^tm1.1Jdun/Heph^tm1.1Jdun Tg(Rho-cre)#Yzl/0
Genetic Background	involves: 129X1/SvJ * C57BL/6NTac

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196540 )

N	• mice exhibit normal retinal pigment epithelium iron levels

Allelic Composition	Heph^tm1.1Jdun/Heph^tm1.1Jdun Tg(Rho-cre)#Yzl/0
Genetic Background	involves: C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Heph^tm1.1Jdun mutation (0 available); any Heph mutation (11 available)
Tg(Rho-cre)#Yzl mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196540 )

N	• mice exhibit normal retinal pigment epithelium iron levels

Allelic Composition	Elovl4^tm3Kzh/Elovl4^tm3Kzh Tg(Rho-cre)#Yzl/?
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elovl4^tm3Kzh mutation (0 available); any Elovl4 mutation (36 available)
Tg(Rho-cre)#Yzl mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:194246 )

N	• no rod loss • no marked abnormalities in the number of photoreceptor cell rows or outer nuclear layer thickness • no ultrastructural abnormalities • normal ERG and normal visual performance up to 6.5 months

abnormal retina rod cell morphology ( J:194246 )

• statistically significant decrease in very long chain polyunsaturated fatty acid content of rods

homeostasis/metabolism

decreased unsaturated fatty acids level ( J:194246 )

• statistically significant decrease in very long chain polyunsaturated fatty acid content of rods

nervous system

abnormal retina rod cell morphology ( J:194246 )

• statistically significant decrease in very long chain polyunsaturated fatty acid content of rods

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