Phenotypes associated with this allele

• Allele Symbol: Cr2^tm1.1Jhws
• Allele Name: targeted mutation 1.1, John Weiss
• Allele ID: MGI:4417922
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cr2^tm1.1Jhws/Cr2^tm1.1Jhws	B6.Cg-Cr2^tm1.1Jhws	MGI:4417923
hm2	Cr2^tm1.1Jhws/Cr2^tm1.1Jhws	Not Specified	MGI:5547494

Genotype
MGI:4417923

hm1

• Allelic Composition: Cr2^tm1.1Jhws/Cr2^tm1.1Jhws
• Genetic Background: B6.Cg-Cr2^tm1.1Jhws

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:155241 )

N • mice exhibit normal B cell types

Genotype
MGI:5547494

hm2

• Allelic Composition: Cr2^tm1.1Jhws/Cr2^tm1.1Jhws
• Genetic Background: Not Specified

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:205353 )

• in mice infected with S. pneumoniae

immune system

immune system phenotype ( J:205353 )

N • IgG1 levels are normal in response to TNP-LPS, DNP-Ficoll or TNP-KLH (10ug or 100ug)

decreased B-1a cell number ( J:205353 )

• compared with wild-type mice

abnormal germinal center B cell physiology ( J:205353 )

• failure to produce activated germinal center B cells after sheep red blood cell immunization unlike wild-type mice

decreased IgG2b level ( J:205353 )

• compared with wild-type mice

• in response to TNP-KLH (10ug or 100ug)

• however, levels are normal in response to TNP-LPS

decreased IgG2c level ( J:205353 )

• compared with wild-type mice

• in response to DNP-Ficoll or TNP-KLH (10ug)

• however, levels are normal in response to TNP-LPS or TNP-KLH (100ug)

decreased IgG3 level ( J:205353 )

• compared with Cr2^tm2.1Jhws homozygotes

• in response to DNP-Ficoll or TNP-KLH (10ug or 100ug)

• however, levels are normal in response to TNP-LPS

decreased IgM level ( J:205353 )

• in response to TNP-KLH (100ug)

• however, levels are normal in response to TNP-LPS, DNP-Ficoll or 10ug TNP-KLH

increased susceptibility to bacterial infection induced morbidity/mortality ( J:205353 )

• in mice infected with S. pneumoniae

hematopoietic system

decreased B-1a cell number ( J:205353 )

• compared with wild-type mice

abnormal germinal center B cell physiology ( J:205353 )

• failure to produce activated germinal center B cells after sheep red blood cell immunization unlike wild-type mice

decreased IgG2b level ( J:205353 )

• compared with wild-type mice

• in response to TNP-KLH (10ug or 100ug)

• however, levels are normal in response to TNP-LPS

decreased IgG2c level ( J:205353 )

• compared with wild-type mice

• in response to DNP-Ficoll or TNP-KLH (10ug)

• however, levels are normal in response to TNP-LPS or TNP-KLH (100ug)

decreased IgG3 level ( J:205353 )

• compared with Cr2^tm2.1Jhws homozygotes

• in response to DNP-Ficoll or TNP-KLH (10ug or 100ug)

• however, levels are normal in response to TNP-LPS

decreased IgM level ( J:205353 )

• in response to TNP-KLH (100ug)

• however, levels are normal in response to TNP-LPS, DNP-Ficoll or 10ug TNP-KLH