About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(KRT14-Fyn*)aJsey
transgene insertion a, John Seykora
MGI:4417930
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(KRT14-Fyn*)aJsey/0 involves: C57BL/6 * CBA MGI:4417937
tg2
Tg(KRT14-Fyn*)aJsey/0 involves: C57BL/6 * CBA * FVB/N MGI:4417941


Genotype
MGI:4417937
tg1
Allelic
Composition
Tg(KRT14-Fyn*)aJsey/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-Fyn*)aJsey mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 15 out of 116 transgenic mice develop spontaneous squamous cell carcinomas (SCC) between ages 3 and 7 months
• enlarged keratinocytes with nuclear atypia, mitotic activity, dermal invasion, and focal keratinization

integument
• cytologic atypia and architectural disorganization in hyperkeratotic plaques
• increased mitotic activity in hyperkeratotic plaques
• enlarged keratinocytes with nuclear atypia, mitotic activity, dermal invasion, and focal keratinization in SCC
• 72 out of 116 transgenic mice develop multiple hyperkeratotic plaques in the epidermis
• detectable at ages 3 to 4 days and persist until ages 3 to 4 weeks
• markedly thickened epidermis in hyperkeratotic plaques
• 15 out of 116 transgenic mice develop spontaneous squamous cell carcinomas (SCC) between ages 3 and 7 months
• enlarged keratinocytes with nuclear atypia, mitotic activity, dermal invasion, and focal keratinization




Genotype
MGI:4417941
tg2
Allelic
Composition
Tg(KRT14-Fyn*)aJsey/0
Genetic
Background
involves: C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-Fyn*)aJsey mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• spontaneous squamous cell carcinomas (SCC) formation in 64 out of 176 transgenic mice
• develop multiple tumors between 5 and 8 weeks
• enlarged keratinocytes with nuclear atypia, mitotic activity, dermal invasion, and focal keratinization in SCC
• no metastasis after following for at least 6 months

integument
• hyperkeratosis in punctate hyperkeratotic lesions
• parakeratosis (retained nuclei in the stratum corneum) in punctate hyperkeratotic lesions
• cytologic atypia and architectural disorganization in hyperkeratotic plaques and lesions
• increased mitotic activity in hyperkeratotic plaques
• enlarged keratinocytes with nuclear atypia, mitotic activity, dermal invasion, and focal keratinization in SCC
• keratinocyte dysplasia in punctate hyperkeratotic lesions
• 135 out of 176 transgenic mice develop hyperkeratotic plaques within 4 days postnatal
• punctate (1-3 mm) hyperkeratotic lesions (resembling a human actinic keratosis) at 4 to 5 weeks
• markedly thickened epidermis in hyperkeratotic plaques
• spontaneous squamous cell carcinomas (SCC) formation in 64 out of 176 transgenic mice
• develop multiple tumors between 5 and 8 weeks
• enlarged keratinocytes with nuclear atypia, mitotic activity, dermal invasion, and focal keratinization in SCC
• no metastasis after following for at least 6 months

cellular
• keratinocyte dysplasia in punctate hyperkeratotic lesions

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
skin squamous cell carcinoma DOID:3151 J:155536





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory