Phenotypes associated with this allele

• Allele Symbol: Foxa2^tm1.1Stf
• Allele Name: targeted mutation 1.1, Markus Stoffel
• Allele ID: MGI:4417942
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Foxa2^tm1.1Stf/Foxa2^tm1.1Stf	B6.129-Foxa2^tm1.1Stf	MGI:4417950
cn2	Foxa2^tm1.1Stf/Foxa2^tm1.1Stf Tg(Nes-cre)1Kln/0	B6.Cg-Foxa2^tm1.1Stf Tg(Nes-cre)1Kln	MGI:4417949

Genotype
MGI:4417950

cn1

• Allelic Composition: Foxa2^tm1.1Stf/Foxa2^tm1.1Stf
• Genetic Background: B6.129-Foxa2^tm1.1Stf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased fluid intake ( J:155391 )

• when injected with cre-expressing adenovirus

increased food intake ( J:155391 )

• when injected with cre-expressing adenovirus

hyperactivity ( J:155391 )

• 4-fold compared to in wild-type mice

homeostasis/metabolism

increased carbon dioxide production ( J:155391 )

• when injected with cre-expressing adenovirus

increased oxygen consumption ( J:155391 )

• when injected with cre-expressing adenovirus

Genotype
MGI:4417949

cn2

• Allelic Composition: Foxa2^tm1.1Stf/Foxa2^tm1.1Stf; Tg(Nes-cre)1Kln/0
• Genetic Background: B6.Cg-Foxa2^tm1.1Stf Tg(Nes-cre)1Kln

homeostasis/metabolism

decreased circulating glucose level ( J:155391 )

• in fed mice and mice fed a high fat diet

decreased circulating insulin level ( J:155391 )

• in fasting mice and mice fed a high fat diet

decreased circulating free fatty acids level ( J:155391 )

• in mice fed regular chow or a high fat diet

increased carbon dioxide production ( J:155391 )

increased oxygen consumption ( J:155391 )

improved glucose tolerance ( J:155391 )

• glucose clearance is modestly increased compared to in wild-type mice

increased insulin sensitivity ( J:155391 )

• indicated by reduced fasting plasma insulin and free fatty acid

increased basal metabolism ( J:155391 )

behavior/neurological

increased fluid intake ( J:155391 )

• in mice fed a high fat diet

increased food intake ( J:155391 )

• in mice fed regular chow or a high fat diet

hyperactivity ( J:155391 )

adipose tissue

decreased total body fat amount ( J:155391 )

• in mice fed regular chow or a high fat diet

growth/size/body

increased lean body mass ( J:155391 )

• in mice fed regular chow or a high fat diet