Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(RNU6-RNAi:Trpv1)Thch}
• Allele Name: targeted mutation 1, Thomas Christoph
• Allele ID: MGI:4418115
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gt(ROSA)26Sor^tm1(RNU6-RNAi:Trpv1)Thch/Gt(ROSA)26Sor^+	Not Specified	MGI:4418129

Genotype
MGI:4418129

ht1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(RNU6-RNAi:Trpv1)Thch}/Gt(ROSA)26Sor⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal chemical nociception ( J:132700 )

• capsaicin-treated mice exhibit less of a nocifensive response compared with similarly treated wild-type mice

abnormal pain threshold ( J:132700 )

• following spinal nerve ligation, mice fail to develop tactile hypersensitivity and allodynia unlike similarly treated wild-type mice

increased thermal nociceptive threshold ( J:132700 )

homeostasis/metabolism

abnormal body temperature ( J:132700 )

• capsaicin-treated mice exhibit only short-lasting and mild body temperature reduction compared with similarly treated wild-type mice

abnormal physiological response to xenobiotic ( J:132700 )

• capsaicin-treated mice exhibit only short-lasting and mild body temperature reduction compared with similarly treated wild-type mice

• capsaicin-treated mice exhibit less of a nocifensive response compared with similarly treated wild-type mice